The neuromuscular junction in health and disease: molecular mechanisms governing synaptic formation and homeostasis

PM Rodríguez Cruz, J Cossins, D Beeson… - Frontiers in molecular …, 2020 - frontiersin.org
The neuromuscular junction (NMJ) is a highly specialized synapse between a motor neuron
nerve terminal and its muscle fiber that are responsible for converting electrical impulses …

Neuromuscular junction formation, aging, and disorders

L Li, WC Xiong, L Mei - Annual review of physiology, 2018 - annualreviews.org
Synapses, the fundamental unit in neuronal circuits, are critical for learning and memory,
perception, thinking, and reaction. The neuromuscular junction (NMJ) is a synapse formed …

[HTML][HTML] Mechanisms regulating neuromuscular junction development and function and causes of muscle wasting

LA Tintignac, HR Brenner… - Physiological …, 2015 - journals.physiology.org
The neuromuscular junction is the chemical synapse between motor neurons and skeletal
muscle fibers. It is designed to reliably convert the action potential from the presynaptic …

Ultrafast synaptic events in a chalcogenide memristor

Y Li, Y Zhong, L Xu, J Zhang, X Xu, H Sun, X Miao - Scientific reports, 2013 - nature.com
Compact and power-efficient plastic electronic synapses are of fundamental importance to
overcoming the bottlenecks of developing a neuromorphic chip. Memristor is a strong …

Neuromuscular synaptogenesis: coordinating partners with multiple functions

H Darabid, AP Perez-Gonzalez… - Nature Reviews …, 2014 - nature.com
The formation of highly efficient and reliable synapses at the neuromuscular junction (NMJ)
relies on dynamic molecular interactions. Studies of the development and maturation of the …

Local and global predictors of synapse elimination during motor learning

NG Hedrick, WJ Wright, T Komiyama - Science Advances, 2024 - science.org
During learning, synaptic connections between excitatory neurons in the brain display
considerable dynamism, with new connections being added and old connections …

Roles for neuronal and glial autophagy in synaptic pruning during development

OJ Lieberman, AF McGuirt, G Tang, D Sulzer - Neurobiology of Disease, 2019 - Elsevier
The dendritic protrusions known as spines represent the primary postsynaptic location for
excitatory synapses. Dendritic spines are critical for many synaptic functions, and their …

Synaptic inputs compete during rapid formation of the calyx of Held: a new model system for neural development

PS Holcomb, BK Hoffpauir, MC Hoyson… - Journal of …, 2013 - Soc Neuroscience
Hallmark features of neural circuit development include early exuberant innervation followed
by competition and pruning to mature innervation topography. Several neural systems …

[HTML][HTML] Structure and function of the mammalian neuromuscular junction

LA Davis, MJ Fogarty, A Brown… - Comprehensive …, 2022 - ncbi.nlm.nih.gov
The mammalian neuromuscular junction (NMJ) comprises a presynaptic terminal, a
postsynaptic receptor region on the muscle fiber (endplate), and the perisynaptic (terminal) …

Morphological variability is greater at developing than mature mouse neuromuscular junctions

AM Mech, AL Brown, G Schiavo… - Journal of Anatomy, 2020 - Wiley Online Library
The neuromuscular junction (NMJ) is the highly specialised peripheral synapse formed
between lower motor neuron terminals and muscle fibres. Post‐synaptic acetylcholine …