Cells organize many of their biochemical reactions in non-membrane compartments. Recent
evidence has shown that many of these compartments are liquids that form by phase …

The intracellular environment represents an extremely crowded milieu, with a limited amount
of free water and an almost complete lack of unoccupied space. Obviously, slightly salted …

INTRODUCTION The formation of dynamic, membraneless compartments using intracellular
phase transitions such as phase separation and gelation provides an efficient way for cells …

RNA-protein (RNP) granules have been proposed to assemble by forming solid RNA/protein
aggregates or through phase separation into a liquid RNA/protein phase. Which model …

Cells can enter into a dormant state when faced with unfavorable conditions. However, how
cells enter into and recover from this state is still poorly understood. Here, we study …

How cells adapt to varying environmental conditions is largely unknown. Here, we show
that, in budding yeast, the RNA-binding and stress granule protein Pub1 has an intrinsic …

One of the grand challenges of biophysical chemistry is to understand the principles that
govern protein misfolding and aggregation, which is a highly complex process that is …

Why do cells age? Recent advances show that the cytoplasm is organized into many
membrane‐less compartments via a process known as phase separation, which ensures …

Macromolecular crowding affects the activity of proteins and functional macromolecular
complexes in all cells, including bacteria. Crowding, together with physicochemical …

The self-association of proteins into symmetric complexes is ubiquitous in all kingdoms of
life,,,,,. Symmetric complexes possess unique geometric and functional properties, but their …