Prostate cancer is the second-leading cause of cancer-related mortality in men in Western
societies. Androgen receptor (AR) signaling is a critical survival pathway for prostate cancer …

The normal development and maintenance of the prostate is dependent on androgen acting
through the androgen receptor (AR). AR remains important in the development and …

Abstract PTEN loss or PI3K/AKT signaling pathway activation correlates with human prostate
cancer progression and metastasis. However, in preclinical murine models, deletion of Pten …

The transcriptional programs regulated through the activity of the androgen receptor (AR)
modulate normal prostate development and the maintenance of prostatic functions at …

Combinatorial activation of PI3-kinase and RAS signaling occurs frequently in advanced
prostate cancer and is associated with adverse patient outcome. We now report that the …

Androgen receptors (ARs) are phosphorylated at multiple sites in response to ligand
binding, but the kinases mediating AR phosphorylation and the importance of these kinases …

Androgen deprivation is still the standard systemic therapy for metastatic prostate cancer
(PCa), but patients invariably relapse with a more aggressive form of PCa termed hormone …

An increase in the activity of mitogen-activated protein kinase (MAPK) has been correlated
with the progression of prostate cancer to advanced disease in humans. The …

An important clinical challenge in prostate cancer therapy is the inevitable transition from
androgen-sensitive to castration-resistant and metastatic prostate cancer. Albeit the …

The cells of the prostate gland are dependent on cell signaling pathways to regulate their
growth, maintenance and function. However, perturbations in key signaling pathways …