Dystonia is a clinically and genetically highly heterogeneous neurological disorder
characterized by abnormal movements and postures caused by involuntary sustained or …

Dystonia is a neurological condition characterized by abnormal involuntary movements or
postures owing to sustained or intermittent muscle contractions. Dystonia can be the …

The view that sleep is essential for survival is supported by the ubiquity of this behavior, the
apparent existence of sleep-like states in the earliest animals, and the fact that severe sleep …

G protein–coupled receptor (GPCR) signaling is precisely controlled to avoid
overstimulation that results in detrimental consequences. Gβγ signaling is negatively …

The underlying molecular basis for neurodevelopmental or neuropsychiatric disorders is not
known. In contrast, mechanistic understanding of other brain disorders including …

Heterotrimeric G proteins can be regulated by posttranslational modifications, including
ubiquitylation. KCTD5, a pentameric substrate receptor protein consisting of an N-terminal …

Sleep debt accumulates during wakefulness, leading to increased slow wave activity (SWA)
during sleep, an encephalographic marker for sleep need. The use-dependent demands of …

Excessive daytime sleepiness (EDS) is classically viewed as a consequence of insufficient
sleep or a symptom of sleep disorders. Epidemiological and clinical evidence have shown …

Abstract Purpose of Review Since the advent of next-generation sequencing, the number of
genes associated with dystonia has been growing exponentially. We provide here a …

Circadian rhythms are driven by a transcription–translation feedback loop that separates
anabolic and catabolic processes across the Earth's 24-h light–dark cycle. Central …