Nucleobase editors comprising nucleic acid programmable DNA binding proteins
2019-03-13 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
AAV delivery of nucleobase editors
DR Liu, JM Levy, WH Yeh - US Patent 11,306,324, 2022 - Google Patents
2018-02-22 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Evolved cas9 proteins for gene editing
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …
are useful for engineering Cas9 and Cas9 variants that have increased activity on target …
Programmable cas9-recombinase fusion proteins and uses thereof
DR Liu, B Chaikind, JL Bessen - US Patent 11,661,590, 2023 - Google Patents
2019-02-25 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
High efficiency base editors comprising Gam
Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that
are useful for the targeted editing of nucleic acids, including editing a single site within the …
are useful for the targeted editing of nucleic acids, including editing a single site within the …
Aptazyme-embedded guide RNAs for use with CRISPR-Cas9 in genome editing and transcriptional activation
2022-07-14 Assigned to PRESIDENT AND FELLOWS OF HARVARD COLLEGE
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
reassignment PRESIDENT AND FELLOWS OF HARVARD COLLEGE ASSIGNMENT OF …
Methods and compositions for evolving base editors using phage-assisted continuous evolution (PACE)
DR Liu, B Thuronyi, CG Wilson - US Patent 11,732,274, 2023 - Google Patents
The instant specification provides for evolved base editors which overcome deficiencies of
those in art (including increased efficiency and/or decreased requirement for specific …
those in art (including increased efficiency and/or decreased requirement for specific …
Uses of adenosine base editors
The disclosure provides methods and compositions for treating blood diseases/disorders,
such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia. For …
such as sickle cell disease, hemochromatosis, hemophilia, and beta-thalassemia. For …
Adenosine nucleobase editors and uses thereof
DR Liu, N Gaudelli - US Patent 11,702,651, 2023 - Google Patents
The disclosure provides adenosine deaminases that are capable of deaminating adenosine
in DNA. The disclosure also provides fusion proteins comprising a Cas9 (eg, a Cas9 …
in DNA. The disclosure also provides fusion proteins comprising a Cas9 (eg, a Cas9 …