Remodeling changes in paradental tissues are considered essential in effecting orthodontic
tooth movement. The force-induced tissue strain produces local alterations in vascularity, as …

CD40 is a cell surface receptor that belongs to the tumor necrosis factor‐R (TNF‐R) family,
and that was first identified and functionally characterized on B lymphocytes. Its critical role …

▪ Abstract CD40-CD154–mediated contact-dependent signals between B and T cells are
required for the generation of thymus dependent (TD) humoral immune responses. CD40 …

Allergic individuals exposed to minute quantities of allergen experience an immediate
response. Immediate hypersensitivity reflects the permanent sensitization of mucosal mast …

Immune thrombocytopenia (ITP) is an autoantibody-mediated bleeding disorder with both
accelerated platelet destruction and impaired platelet production. We and others have …

The generation of Ig-secreting cells (ISCs) from memory B cells requires interactions
between antigen-specific (Ag-specific) B cells, T cells, and dendritic cells. This process must …

Today, multiple lines of evidence support the view of atherosclerosis as a chronic
inflammatory disease and implicate components of the immune system in atherogenesis …

Antigen presenting cells recognize pathogens via pattern recognition receptors (PRR),
which upon ligation transduce intracellular signals that can induce innate immune …

Why systemic lupus erythematosus primarily affects women is unknown. Recent evidence
indicates that human lupus is an epigenetic disease characterized by impaired T cell DNA …

Recently, we have demonstrated that human platelets carry preformed CD40 ligand
(CD154) molecules, which rapidly appear on the platelet surface following stimulation by …