In human pathophysiology, the clash between microbial infection and host immunity
contributes to multiple diseases. Cystic fibrosis (CF) is a classical example of this …

The Pseudomonas quinolone signal (PQS) has been studied primarily in the context of its
role as a quorum-sensing signaling molecule. Recent data suggest, however, that this …

Secondary metabolites profoundly affect microbial physiology, metabolism and stress
responses. Increasing evidence suggests that these molecules can modulate microbial …

Bacteria become highly tolerant to antibiotics when nutrients are limited. The inactivity of
antibiotic targets caused by starvation-induced growth arrest is thought to be a key …

Bacteria encounter a myriad of stresses in their natural environments, including, for
pathogens, their hosts. These stresses elicit a variety of specific and highly regulated …

Lung infection is the main cause of morbidity and mortality in patients with cystic fibrosis and
is mainly dominated by Pseudomonas aeruginosa. The biofilm mode of growth makes …

Antibiotics, considered as a backbone of modern clinical-medicines, are facing serious
threats from emerging antimicrobial-resistance (AMR) in several bacteria from nosocomial …

Since quinine was first isolated, animals, plants and microorganisms producing a wide
variety of quinolone compounds have been discovered, several of which possess …

Bacteria employ sophisticated cell-to-cell communication or 'quorum sensing'(QS) systems
for promoting collective behaviours that depend on the actions of one or more chemically …

Experimental approaches primarily focused on genetic and microscopic techniques have
laid the foundation for our current models of bacterial biofilm formation. This work has …