Compared with traditional therapies, targeted therapy has merits in selectivity, efficacy, and
tolerability. Small molecule inhibitors are one of the primary targeted therapies for cancer …

Simple Summary Glioblastoma is the most common malignant brain tumor associated with a
poor prognosis, with a median survival of 14 months. Despite initial treatment with surgery …

The large diversity of central nervous system (CNS) tumor types in children and adolescents
results in disparate patient outcomes and renders accurate diagnosis challenging. In this …

Purpose: Current glioma diagnostic guidelines call for molecular profiling to stratify patients
into prognostic and treatment subgroups. In case the tumor tissue is inaccessible …

Background Larotrectinib is a first-in-class, highly selective, and central nervous system-
active tropomyosin receptor kinase (TRK) inhibitor approved for the treatment of adult and …

Glioma is the most common malignant intracranial tumor and exhibits diffuse metastasis and
a high recurrence rate. The invasive property of glioma results from cell detachment. Anoikis …

Virtually all glioblastomas treated in the first-line setting will recur in a short period of time,
and the search for alternative effective treatments has so far been unsuccessful. Various …

Abstract Purpose of Review Molecular profiling enables the evaluation of genetic alterations
for the diagnosis and classification of gliomas and the selection of appropriate therapies …

Central nervous system (CNS) tumors are the leading cause of pediatric cancer death, and
these patients have an increased risk for developing secondary neoplasms. Due to the low …

PURPOSE INFORM is an international pediatric precision oncology registry, prospectively
collecting molecular and clinical data of children with recurrent, progressive, or very high …