Ketamine was introduced into clinical practice in the 1960s and continues to be both
clinically useful and scientifically fascinating. With considerably diverse molecular targets …

The history of ketamine begins in the 1950s at Parke-Davis and Company's laboratories in
Detroit, Michigan, USA. At that time, Parke-Davis were searching among cyclohexylamines …

New Hypnotic Drug Development and Pharmacologic Considerations for Clinical Anesthesia -
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While phencyclidine (PCP) and ketamine remain the most well-studied and widely known
dissociative drugs, a number of other agents have appeared since the late 1950s and early …

Recently, the new psychoactive substance (NPS) ketamine analogue 2-fluoro-
deschloroketamine (2FDCK) was observed in driving-under-the-influence-of-drugs whole …

Objective Calabadion 2 is a new drug-encapsulating agent. In this study, we aim to assess
its utility as an agent to reverse general anesthesia with etomidate and ketamine and …

Ketamine is a short-acting general anesthetic with hallucinogenic, analgesic, and amnestic
properties. In addition to its anesthetic use, ketamine is commonly abused in rave settings …

Drug discovery is the cornerstone of developments in the field of anesthesia. Each year, new
drugs enter the market and possibly change clinical practice. The development of new …

Background and aim: Endoscopic retrograde cholangiopancreatography (ERCP) requires
moderate-to-deep conscious sedation. Combinations of ketamine and propofol (ketofol) and …

Ketamine [2-(2-chlorophenyl)-2-(methylamino) cyclohexanone] is a dissociative anaesthetic,
first developed in 1963 by Parke-Davis. It finds widespread application in the treatment of …