Mechanical properties of extracellular matrices (ECMs) regulate essential cell behaviours,
including differentiation, migration and proliferation, through mechanotransduction. Studies …

The extracellular matrix (ECM) is a highly dynamic system that constantly offers physical,
biological, and chemical signals to embraced cells. Increasing evidence suggests that …

Graft-host mechanical mismatch has been a longstanding issue in clinical applications of
synthetic scaffolds for soft tissue regeneration. Although numerous efforts have been …

Metastasis causes most cancer-related deaths; however, the efficacy of anti-metastatic drugs
is limited by incomplete understanding of the biological mechanisms that drive metastasis …

Integrin-dependent adhesion to the extracellular matrix (ECM) mediates mechanosensing
and signaling in response to altered microenvironmental conditions. In order to provide …

The extracellular matrix (ECM) is pivotal in modulating tumor progression. Besides
chemically stimulating tumor cells, it also offers physical support that orchestrates the …

The directed migration of cellular clusters enables morphogenesis, wound healing and
collective cancer invasion. Gradients of substrate stiffness direct the migration of cellular …

Extracellular matrix (ECM) rigidity serves as a crucial mechanical cue impacting diverse
biological processes. However, understanding the molecular mechanisms of rigidity sensing …

Mechanical cues in the cell microenvironment such as those from extracellular matrix
properties, stretching, compression and shear stress, play a critical role in maintaining …

The filamentous actin (F-actin) cytoskeleton is a composite material consisting of cortical
actin and bundled F-actin stress fibers, which together mediate the mechanical behaviors of …