This review focuses on the human pancreatic islet—including its structure, cell composition,
development, function, and dysfunction. After providing a historical timeline of key …

The exponential increase of patients with diabetes mellitus urges for novel therapeutic
strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of …

Both basal and glucose-stimulated insulin release occur primarily by insulin secretory
granule exocytosis from pancreatic β cells, and both are needed to maintain normoglycemia …

β-Cell replacement by in situ reprogramming of non-β-cells is a promising diabetes therapy.
Following the observation that near-total β-cell ablation in adult mice triggers the …

Pancreatic β-cells perform glucose-stimulated insulin secretion, a process at the center of
type 2 diabetes etiology. Efforts to understand how β-cells behave in healthy and stressful …

Improving our understanding of mammalian pancreas development is crucial for the
development of more effective cellular therapies for diabetes. Most of what we know about …

Next generation sequencing studies have highlighted discrepancies in β-cells which exist
between mice and men. Numerous reports have identified MAF BZIP Transcription Factor B …

Pancreatic β-cells are specialized to properly regulate blood glucose. Maintenance of the
mature β-cell phenotype is critical for glucose metabolism, and β-cell failure results in …

The physiological functions of many vital tissues and organs continue to mature after birth,
but the genetic mechanisms governing this postnatal maturation remain an unsolved …

A heterozygous missense mutation of the islet β cell-enriched MAFA transcription factor (p.
Ser64Phe [S64F]) is found in patients with adult-onset β cell dysfunction (diabetes or …