Children harboring certain germline gene variants have an increased risk of developing
myelodysplastic syndrome (MDS) and other hematopoietic malignancies (HM), such as …

Highlights•Enhancer function in normal cells and disease is still not fully understood.•Protein
complexes drive enhancer-promoter proximity.•MLL rearranged leukemias assemble …

Gene therapy using hematopoietic stem and progenitor cells is altering the therapeutic
landscape for patients with hematologic, immunologic, and metabolic disorders but has not …

Hematopoietic homeostasis is maintained by hematopoietic stem cells (HSCs), and it is
tightly controlled at multiple levels to sustain the self-renewal capacity and differentiation …

Epidemiological evidence of familial predispositions to myeloid malignancies and
myeloproliferative neoplasms (MPN) has long been recognised, but recent studies have …

Pol II pause release is a rate‐limiting step in gene transcription, influencing various cell fate
alterations. Numerous proteins orchestrate Pol II pause release, thereby playing pivotal …

A novel target folate receptor and CD44 receptor are deliberated for effective as
chemotherapeutic agents. Usually, these receptors are play a vital role in the functional …