Ebola viruses and Marburg viruses, members of the filovirus family, are zoonotic pathogens
that cause severe disease in people, as highlighted by the latest Ebola virus epidemic in …

Ebola virus (EBOV), member of genus Ebolavirus, family Filoviridae, have a non-segmented,
single-stranded RNA that contains seven genes:(a) nucleoprotein (NP),(b) viral protein 35 …

Intracellular recognition of non‐self and also self‐nucleic acids can result in the initiation of
potent pro‐inflammatory and antiviral cytokine responses. Most recently, cGAS was shown …

Lassa fever virus, a member of the family Arenaviridae, is a highly endemic category A
pathogen that causes 300,000–500,000 infections per year in Western Africa. The arenaviral …

Middle East respiratory syndrome coronavirus (MERS-CoV) causes severe acute respiratory
infection with as yet unclear epidemiology. We previously showed that MERS-CoV …

Previous studies have shown that both hepatitis A virus and hepatitis C virus inhibit innate
immunity by cleaving the mitochondrial antiviral signaling (MAVS) protein, an essential …

The cytoplasmic pattern recognition receptor RIG-I is activated by viral RNA and induces
type I IFN responses to control viral replication. The cellular dsRNA binding protein PACT …

Ebolavirus NP oligomerizes into helical filaments found at the core of the virion,
encapsidates the viral RNA genome, and serves as a scaffold for additional viral proteins …

Ebolaviruses cause hemorrhagic fever with up to 90% lethality and in fatal cases, are
characterized by early suppression of the host innate immune system. One of the proteins …

Ebola causes highly lethal hemorrhagic fever in humans with no licensed countermeasures.
Its virulence can be attributed to several immunoevasion mechanisms: an early inhibition of …