An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …

The spread of bacterial drug resistance has posed a severe threat to public health globally.
Here, we cover bacterial resistance to current antibacterial drugs, including traditional herbal …

The increasing resistance of bacteria to existing antibiotics constitutes a major public health
threat globally. Most current antibiotic treatments are hindered by poor delivery to the …

Molecular de-extinction could offer avenues for drug discovery by reintroducing bioactive
molecules that are no longer encoded by extant organisms. To prospect for antimicrobial …

Cutaneous mast cells (MCs) express Mas-related G protein–coupled receptor-X2
(MRGPRX2; mouse ortholog MrgprB2), which is activated by an ever-increasing number of …

Antimicrobial peptides (AMPs) derived from natural toxins and venoms offer a promising
alternative source of antibiotics. Here, through structure-function-guided design, we convert …

Antibiotic resistance is one of the greatest challenges of our time. This global health problem
originated from a paucity of truly effective antibiotic classes and an increased incidence of …

Sepsis, a widely recognized disease, is characterized by multiple pathogen infections.
Therefore, it is imperative to develop methods that can efficiently identify and neutralize …

The prevalence of multidrug-resistant (MDR) pathogens raises public fears of untreatable
infections and represents a huge health risk. There is an urgent need to exploit novel …

Bacterial drug resistance is becoming increasingly serious, and it is urgent to develop
effective antibacterial drugs. Antimicrobial peptides (AMPs), as potential candidates against …