Carbon monoxide and its controlled release: therapeutic application, detection, and development of carbon monoxide releasing molecules (CORMs) miniperspective

K Ling, F Men, WC Wang, YQ Zhou… - Journal of Medicinal …, 2017 - ACS Publications
Carbon monoxide (CO) is attracting increasing attention because of its role as a
gasotransmitter with cytoprotective and homeostatic properties. Carbon monoxide releasing …

Plight of CORMs: The unreliability of four commercially available CO-releasing molecules, CORM-2, CORM-3, CORM-A1, and CORM-401, in studying CO biology

N Bauer, Z Yuan, X Yang, B Wang - Biochemical Pharmacology, 2023 - Elsevier
Carbon monoxide (CO) is an endogenously produced gaseous signaling molecule with
demonstrated pharmacological effects. In studying CO biology, three delivery forms have …

Carbon‐monoxide‐releasing molecules for the delivery of therapeutic CO in vivo

S García‐Gallego… - Angewandte Chemie …, 2014 - Wiley Online Library
The development of carbon‐monoxide‐releasing molecules (CORMs) as pharmaceutical
agents represents an attractive and safer alternative to administration of gaseous CO. Most …

Ruthenium complexes in the fight against pathogenic microorganisms. An extensive review

AC Munteanu, V Uivarosi - Pharmaceutics, 2021 - mdpi.com
The widespread use of antibiotics has resulted in the emergence of drug-resistant
populations of microorganisms. Clearly, one can see the need to develop new, more …

Controlled therapeutic delivery of CO from carbon monoxide-releasing molecules (CORMs)

HI Choi, A Zeb, MS Kim, I Rana, N Khan… - Journal of Controlled …, 2022 - Elsevier
Carbon monoxide (CO) has been regarded as a “silent killer” for its toxicity toward biological
systems. However, a low concentration of endogenously produced CO has shown a number …

CO-releasing molecule (CORM) conjugate systems

AC Kautz, PC Kunz, C Janiak - Dalton Transactions, 2016 - pubs.rsc.org
The development of CORMs (CO-releasing molecules) as a prodrug for CO administration in
living organisms has attracted significant attention. CORMs offer the promising possibility of …

[HTML][HTML] A thiol-reactive Ru (II) ion, not CO release, underlies the potent antimicrobial and cytotoxic properties of CO-releasing molecule-3

HM Southam, TW Smith, RL Lyon, C Liao, CR Trevitt… - Redox biology, 2018 - Elsevier
Carbon monoxide (CO)-releasing molecules (CORMs), mostly metal carbonyl compounds,
are extensively used as experimental tools to deliver CO, a biological 'gasotransmitter', in …

“CO in a pill”: Towards oral delivery of carbon monoxide for therapeutic applications

X Yang, W Lu, M Wang, C Tan, B Wang - Journal of Controlled Release, 2021 - Elsevier
Along with the impressive achievements in understanding the endogenous signaling roles
and mechanism (s) of action of carbon monoxide (CO), much research has demonstrated …

'Carbon-monoxide-releasing molecule-2 (CORM-2)'is a misnomer: ruthenium toxicity, not CO release, accounts for its antimicrobial effects

HM Southam, MP Williamson, JA Chapman, RL Lyon… - Antioxidants, 2021 - mdpi.com
Carbon monoxide (CO)-releasing molecules (CORMs) are used to deliver CO, a biological
'gasotransmitter', in biological chemistry and biomedicine. CORMs kill bacteria in culture and …

The microbiology of ruthenium complexes

HM Southam, JA Butler, JA Chapman… - Advances in microbial …, 2017 - Elsevier
Ruthenium is seldom mentioned in microbiology texts, due to the fact that this metal has no
known, essential roles in biological systems, nor is it generally considered toxic. Since the …