Despite decades of bile acid research, diverse biological roles for bile acids have been
discovered recently due to developments in understanding the human microbiota. As …

Bidirectional crosstalk along the gut-liver axis controls gastrointestinal health and disease
and exploits environmental and host mediators. Nutrients, microbial antigens, metabolites …

Inflammatory bowel disease (IBD) and colorectal cancer (CRC) are heterogeneous intestinal
diseases that threaten the health of an increasing number of individuals as their lifestyles …

Symbiotic microorganisms inhabiting the gastrointestinal tract promote health by decreasing
susceptibility to infection and enhancing resistance to a range of diseases. In this Review …

Centenarians have a decreased susceptibility to ageing-associated illnesses, chronic
inflammation and infectious diseases 1, 2, 3. Here we show that centenarians have a distinct …

Bile acids play key roles in gut metabolism, cell signaling, and microbiome composition.
While the liver is responsible for the production of primary bile acids, microbes in the gut …

Efforts to model the human gut microbiome in mice have led to important insights into the
mechanisms of host-microbe interactions. However, the model communities studied to date …

The gut microbiota contributes to host physiology through the production of a myriad of
metabolites. These metabolites exert their effects within the host as signalling molecules and …

The diversity, composition, and function of the bacterial community inhabiting the human
gastrointestinal tract contributes to host health through its role in producing energy or …

Calorie restriction (CR) and fasting are common approaches to weight reduction, but the
maintenance is difficult after resuming food consumption. Meanwhile, the gut microbiome …