BAG-1 is multifunctional protein which interacts with a wide range of cellular targets to
regulate growth control pathways important for normal and malignant cells, including …

Pituitary somatotrophs secrete growth hormone (GH) into the bloodstream, to act as a
hormone at receptor sites in most, if not all, tissues. These endocrine actions of circulating …

Abstract The Nuclear Factor (NF)-κB family of transcription factors controls expression of
genes which promote cell growth, survival, and neoplastic transformation. Recently we …

While growth hormone (GH) is classically defined as a peptide hormone, recent evidence
supports a role for GH acting as a cytokine in the immune system under conditions of stress …

Amplification, overexpression, or rearrangement of the c-rel gene, encoding the c-Rel NF-κB
subunit, has been reported in solid and hematopoietic malignancies. For example, many …

Growth hormone (GH) and prolactin (PRL) are both endocrines that are synthesized and
released from the pituitary gland into systemic circulation. Both are therefore hormones and …

Increasing evidence has placed hormones and neuropeptides among potent
immunomodulators, in both health and disease. Herein, we focus on the effects of growth …

The growth hormone (GH)/insulin-like growth factor 1 (IGF-1) axis regulates cardiac growth,
stimulates myocardial contractility and influences the vascular system. The GH/IGF-1 axis …

We have previously demonstrated that IGFBP-5 production by mammary epithelial cells
increases dramatically during involution of the mammary gland. To demonstrate a causal …

Growth hormone (GH) is a major growth-promoting and metabolic regulatory hormone.
Interaction of GH with its cell surface GH receptor (GHR), by virtue of receptor dimerization …