Background: The benefits and harms of intensive insulin therapy (IIT) titrated to strict
glycemic targets in hospitalized patients remain uncertain. Purpose: To evaluate the benefits …

OBJECTIVE—To review performance characteristics of 12 insulin infusion protocols.
RESEARCH DESIGN AND METHODS—We systematically identify and compare 12 …

Aims In acute myocardial infarction (AMI), baseline hyperglycaemia predicts adverse
outcomes, but the relation between subsequent change in glucose levels and outcomes is …

Background With the widespread use of information communication technologies,
computerized clinical practice guidelines are developed and considered as effective …

Background: Consistent compliance with evidence-based guidelines is challenging yet
critical to patient safety. We conducted a qualitative study to explore the underlying causes …

Purpose The blood glucose target range and optimal method to reach this range remain a
matter of debate in the intensive care unit (ICU). A computer decision support system …

Introduction Closed-loop (CL) systems modulate insulin delivery according to glucose levels
without nurse input. In a prospective randomized controlled trial, we evaluated the feasibility …

Tight glycemic control (TGC) has emerged as a major research focus in critical care due to
its potential to simultaneously reduce both mortality and costs. However, repeating initial …

Hyperglycemia is a common feature of the critically ill in general and of patients with sepsis
in particular. Even a moderate degree of hyperglycemia appears detrimental for the outcome …

Background: Guidelines are among us for over 30 years. Initially they were used as
algorithmic protocols by nurses and other ancillary personnel. Many physicians regarded …