Gut microbiome, big data and machine learning to promote precision medicine for cancer

G Cammarota, G Ianiro, A Ahern, C Carbone… - Nature reviews …, 2020 - nature.com
The gut microbiome has been implicated in cancer in several ways, as specific microbial
signatures are known to promote cancer development and influence safety, tolerability and …

Exploring the role of gut microbiome in colon cancer

I Chattopadhyay, R Dhar, K Pethusamy… - Applied biochemistry …, 2021 - Springer
Dysbiosis of the gut microbiome has been associated with the development of colorectal
cancer (CRC). Gut microbiota is involved in the metabolic transformations of dietary …

Colibactin: more than a new bacterial toxin

T Faïs, J Delmas, N Barnich, R Bonnet, G Dalmasso - Toxins, 2018 - mdpi.com
Cyclomodulins are bacterial toxins that interfere with the eukaryotic cell cycle. A new
cyclomodulin called colibactin, which is synthetized by the pks genomic island, was …

Study of the relationship between microbiome and colorectal cancer susceptibility using 16SrRNA sequencing

W Liu, R Zhang, R Shu, J Yu, H Li… - BioMed research …, 2020 - Wiley Online Library
A lot of previous studies have recently reported that the gut microbiota influences the
development of colorectal cancer (CRC) in Western countries, but the role of the gut …

Fusobacterium nucleatum and colorectal cancer: A mechanistic overview

N Hashemi Goradel, S Heidarzadeh… - Journal of Cellular …, 2019 - Wiley Online Library
Colorectal cancer (CRC) is the third most prevalent cancer in the world. There are many risk
factors involved in CRC. According to recent findings, the tumor microenvironment and feces …

The role of microbiota in the development of colorectal cancer

Z Dai, J Zhang, Q Wu, J Chen, J Liu… - … journal of cancer, 2019 - Wiley Online Library
Colorectal cancer is the third largest cancer in worldwide and has been proven to be closely
related to the intestinal microbiota. Many reports and clinical studies have shown that …

A mechanistic model for colibactin-induced genotoxicity

AR Healy, H Nikolayevskiy, JR Patel… - Journal of the …, 2016 - ACS Publications
Precolibactins and colibactins represent a family of natural products that are encoded by the
clb gene cluster and are produced by certain commensal, extraintestinal, and probiotic E …

Gut microbiome as a treatment in colorectal cancer

M Khan, S Shah, W Shah, I Khan, H Ali… - International Reviews …, 2024 - Taylor & Francis
Background The gut microbiome plays a role in the development and progression of
colorectal cancer (CRC). Aim and objective This review focuses on whether the gut …

The gastrointestinal microbiota in colorectal cancer cell migration and invasion

C Henstra, J van Praagh, P Olinga… - Clinical & Experimental …, 2021 - Springer
Colorectal carcinoma is the third most common cancer in developed countries and the
second leading cause of cancer-related mortality. Interest in the influence of the intestinal …

Colibactin possessing E. coli isolates in association with colorectal cancer and their genetic diversity among Pakistani population

H Tariq, Z Noreen, A Ahmad, L Khan, M Ali, M Malik… - Plos one, 2022 - journals.plos.org
Colorectal cancer (CRC) is the third most prevalent cause of tumorigenesis and several
pathogenic bacteria have been correlated with aggressive cases of cancer ie, genotoxin …