Aneuploidy has been recognized as a hallmark of tumorigenesis for more than 100 years,
but the connection between chromosomal errors and malignant growth has remained …

Dividing cells that experience chromosome mis-segregation generate aneuploid daughter
cells, which contain an incorrect number of chromosomes. Although aneuploidy interferes …

In this review we summarize the current understanding of signal transduction downstream of
vascular endothelial growth factor A (VEGFA) and its receptor VEGFR 2, and the relationship …

Genetic instability, which includes both numerical and structural chromosomal
abnormalities, is a hallmark of cancer. Whereas the structural chromosome rearrangements …

Nuclear factor of activated T cells (NFAT) was first identified more than two decades ago as
a major stimulation-responsive DNA-binding factor and transcriptional regulator in T cells. It …

Calcineurin is a calcium activated protein phosphatase with a major role in calcium
signaling in diverse cells and organs and clinical importance as the target of the …

The roles of nuclear factor of activated T cells (NFAT) transcription factors have been
extensively studied in the immune system. However, ubiquitous expression of NFAT …

Most solid human tumours are aneuploid, that is, they contain an abnormal number of
chromosomes. Paradoxically, however, aneuploidy has been reported to induce a stress …

In the absence of growth signals, cells exit the cell cycle and enter into G0 or quiescence.
Alternatively, cells enter senescence in response to inappropriate growth signals such as …

Targeted therapies aimed at tumor vasculature are utilized in combination with
chemotherapy to improve drug delivery and efficacy after tumor vascular normalization …