It is textbook knowledge that carboxamides benefit from increased stabilisation of the
electrophilic carbonyl carbon when compared to other carbonyl and carboxyl derivatives …

In recent years, Hantzsch esters and their related organic hydride donors have been widely
utilized in biomimetic approaches of asymmetric transfer hydrogenation (ATH) reactions …

Fluoroalkyl groups profoundly affect the physical properties of pharmaceuticals and
influence almost all metrics associated with their pharmacokinetic and pharmacodynamic …

The tertiary amide is a ubiquitous functional group and plays an irreplaceable role in
medicinal chemistry. Its robust nature has meant—in the past—that selective manipulation of …

Reduction reactions are among the simplest transformations in organic chemistry, and are
extensively used in both laboratory and industrial processes. 1, 2 Although reduction of a …

We report a uniquely high-yielding, general, and practical ortho bromination and iodination
reaction of different classes of aromatic compounds. This reaction occurs by Rh (III) …

The reduction of amides gives access to a wide variety of important compounds such as
amines, imines, enamines, nitriles, aldehydes and alcohols. The chemoselective …

A bifunctional iminophosphorane (BIMP)-catalyzed, enantioselective intramolecular oxa-
Michael reaction of alcohols to tethered, low electrophilicity Michael acceptors is described …

The nucleophilic addition of carbon nucleophiles to amides has traditionally been a difficult
task, both due to reactivity and selectivity problems. When successful, these processes …

Catalytic reduction of secondary amides to imines and secondary amines has been
achieved using readily available iridium catalysts such as [Ir (COE) 2Cl] 2 with diethylsilane …