Levels and patterns of genetic diversity can provide insights into a population's history. In
species with sex chromosomes, differences between genomic regions with unique …

Levels and patterns of genetic diversity can provide insights into a population's history. In
species with sex chromosomes, differences between genomic regions with unique …

Domestication fundamentally reshaped animal morphology, physiology and behaviour,
offering the opportunity to investigate the molecular processes driving evolutionary change …

Signatures of recent positive selection often overlap across human populations, but the
question of how often these overlaps represent a single ancestral event remains unresolved …

Skin color is a highly heritable human trait, and global variation in skin pigmentation has
been shaped by natural selection, migration and admixture. Ethnically diverse African …

Whole-genome sequencing (WGS) allows for a comprehensive view of the sequence of the
human genome. We present and apply integrated methodologic steps for interrogating WGS …

The relationship between DNA sequence, biochemical function, and molecular evolution is
relatively well-described for protein-coding regions of genomes, but far less clear in …

Background Exome sequencing has advanced to clinical practice and proven useful for
obtaining molecular diagnoses in rare diseases. In approximately 75% of cases, however, a …

Natural selection of beneficial genetic variants played a critical role in human adaptation to a
wide range of environmental conditions. Northern Eurasia, despite its severe climate, is …

The hydrothermal vent tubeworm Ridgeia piscesae relies on intracellular
chemolithoautotrophic symbionts for its nutrition. Yet, little is known about symbiont diversity …