Adolescence encompasses a sensitive developmental period of enhanced clinical
vulnerability to nicotine, tobacco, and e‐cigarettes. While there are sociocultural influences …

Mesocorticolimbic dopamine circuity undergoes a protracted maturation during adolescent
life. Stable adult levels of behavioral functioning in reward, motivational, and cognitive …

Initiating drug use during adolescence increases the risk of developing addiction or other
psychopathologies later in life, with long-term outcomes varying according to sex and exact …

A dramatic maturational process ongoing in adolescence is prefrontal cortex development,
including its dopamine innervation. Dopamine axons grow from the striatum to the prefrontal …

Backgroud Variations in the expression of the Netrin-1 guidance cue receptor DCC (deleted
in colorectal cancer) appear to confer resilience or susceptibility to psychopathologies …

The prefrontal cortex plays a central role in the control of complex cognitive processes
including action control and decision making. It also shows a specific pattern of delayed …

Axon guidance molecules direct growing axons toward their targets, assembling the intricate
wiring of the nervous system. One of these molecules, Netrin-1, and its receptor, DCC …

Background Genome‐wide association studies (GWAS) have made little progress in
identifying variants linked to depression. We hypothesized that examining depressive …

Background Dopaminergic input to the prefrontal cortex (PFC) increases throughout
adolescence and, by establishing precisely localized synapses, calibrates cognitive …

The Netrin-1/DCC guidance cue pathway plays a critical role in guiding growing axons
toward the prefrontal cortex during adolescence and in the maturational organization and …