Abstract Poly (amidoamine) dendrimers (PAMAM) are novel polymeric highly branched
architectures with well-defined nano-size, narrow polydispersity index and numerous active …

The discovery of miRNAs as important regulatory agents for gene expression has expanded
the therapeutic opportunities for oligonucleotides. In contrast to siRNA, miRNA-targeted …

Conspectus Dendrimers, notable for their well-defined radial structures with numerous
terminal functionalities, hold great promise for biomedical applications such as drug …

Dendrimers are three-dimensional macromolecular structures originating from a central core
molecule and surrounded by successive addition of branching layers (generation). These …

Hsp27, αB-crystallin and HSP22 are ubiquitous small heat shock proteins (sHsp) whose
expression is induced in response to a wide variety of unfavorable physiological and …

The potent ability of small interfering RNA (siRNA) to specifically and efficiently inhibit the
expression of complementary RNA transcripts offers a promising alternative therapeutic …

Glioblastoma (GB) is a grade IV astrocytoma that maintains a poor prognosis with respect to
current treatment options. Despite major advancements in the fields of surgery and …

The use of poly (propylenimine)(PPI) dendrimers as gene delivery vectors is limited by their
low transfection efficacy and serious cytotoxicity. In this study, we prepare a series of efficient …

Introduction: This review presents recent developments in the use of nonviral vectors and
transfer technologies in cancer gene therapy. Tremendous progress has been made in …

In this study, we designed and synthesized a biodegradable dendronized polypeptide
(denpol) platform for delivery of small interfering RNA (siRNA). The novel denpol …