Zebrafish as an emerging model for studying complex brain disorders

AV Kalueff, AM Stewart, R Gerlai - Trends in pharmacological sciences, 2014 - cell.com
The zebrafish (Danio rerio) is rapidly becoming a popular model organism in
pharmacogenetics and neuropharmacology. Both larval and adult zebrafish are currently …

Ontogenesis of lateralization

O Güntürkün, S Ocklenburg - Neuron, 2017 - cell.com
The brains of humans and other animals are asymmetrically organized, but we still know
little about the ontogenetic and neural fundaments of lateralizations. Here, we review the …

Transcriptional and spatial resolution of cell types in the mammalian habenula

Y Hashikawa, K Hashikawa, MA Rossi, ML Basiri, Y Liu… - Neuron, 2020 - cell.com
The habenula complex is appreciated as a critical regulator of motivated and pathological
behavioral states via its output to midbrain nuclei. Despite this, transcriptional definition of …

Asymmetry of the brain: development and implications

V Duboc, P Dufourcq, P Blader… - Annual review of …, 2015 - annualreviews.org
Although the left and right hemispheres of our brains develop with a high degree of
symmetry at both the anatomical and functional levels, it has become clear that subtle …

Comprehensive identification and spatial mapping of habenular neuronal types using single-cell RNA-seq

S Pandey, K Shekhar, A Regev, AF Schier - Current Biology, 2018 - cell.com
The identification of cell types and marker genes is critical for dissecting neural development
and function, but the size and complexity of the brain has hindered the comprehensive …

A simple method for 3D analysis of immunolabeled axonal tracts in a transparent nervous system

M Belle, D Godefroy, C Dominici, C Heitz-Marchaland… - Cell reports, 2014 - cell.com
Clearing techniques have been developed to transparentize mouse brains, thereby
preserving 3D structure, but their complexity has limited their use. Here, we show that …

Translating the habenula—from rodents to humans

LJ Boulos, E Darcq, BL Kieffer - Biological psychiatry, 2017 - Elsevier
The habenula (Hb) is a central structure connecting forebrain to midbrain regions. This
microstructure regulates monoaminergic systems, notably dopamine and serotonin, and …

Brain and behavioral asymmetry: A lesson from fish

ME Miletto Petrazzini, VA Sovrano… - Frontiers in …, 2020 - frontiersin.org
It is widely acknowledged that the left and right hemispheres of human brains display both
anatomical and functional asymmetries. For more than a century, brain and behavioral …

Mu opioid receptors in the medial habenula contribute to naloxone aversion

LJ Boulos, S Ben Hamida, J Bailly, M Maitra… - …, 2020 - nature.com
The medial habenula (MHb) is considered a brain center regulating aversive states. The mu
opioid receptor (MOR) has been traditionally studied at the level of nociceptive and …

Toward the use of novel alternative methods in epilepsy modeling and drug discovery

C Miguel Sanz, M Martinez Navarro… - Frontiers in …, 2023 - frontiersin.org
Epilepsy is a chronic brain disease and, considering the amount of people affected of all
ages worldwide, one of the most common neurological disorders. Over 20 novel antiseizure …