Hyaluronic acid (also known as hyaluronan or hyaluronate) is naturally found in many
tissues and fluids, but more abundantly in articular cartilage and synovial fluid (SF) …

Osteoarthritis (OA) is a complex “whole joint” disease pursued by inflammatory mediators,
rather than purely a process of “wear and tear”. Besides cartilage degradation, synovitis …

Hyaluronic acid (HA) is a naturally occurring biodegradable polymer with a variety of
applications in medicine, including scaffolding for tissue engineering, dermatological fillers …

Background: Viscosupplementation, the intra-articular injection of hyaluronic acid, is widely
used for symptomatic knee osteoarthritis. Purpose: To assess the benefits and risks of …

Objective To evaluate the therapeutic trajectory of intra-articular hyaluronic acid (IAHA) vs
placebo for knee osteoarthritis (OA). Design Our data sources include Medline, EMBASE …

Background Osteoarthritis (OA) is the most prevalent chronic joint disorder worldwide and is
associated with significant pain and disability. Objectives To assess the effects of …

Background: Knee osteoarthritis (OA) is a common and often disabling joint disorder among
adults that may result in impaired activity and daily function. A variety of treatment options …

Background: Placebo controls are essential in evaluating the effectiveness of medical
treatments. Although it is unclear whether different placebo interventions for osteoarthritis …

We conducted a systematic review and meta-analysis of randomized saline-controlled trials
to determine the safety and efficacy of US-approved intra-articular hyaluronic acid (IAHA) …

Objectives To quantify the placebo effect of intraarticular injections for knee osteoarthritis in
terms of pain, function, and objective outcomes. Factors influencing placebo effect were …