Folate being an important vitamin of B Complex group in our diet plays an important role not
only in the synthesis of DNA but also in the maintenance of methylation reactions in the …

To evaluate the contribution of candidate gene association studies to the understanding of
genetic susceptibility to childhood acute lymphoblastic leukemia we conducted a systematic …

Acute lymphoblastic leukaemia (ALL) is the most common paediatric cancer, accounting for
nearly 30% of all paediatric cancers and 80% of childhood leukaemias. Polymorphisms in …

Methlenetetrahydrofolate reductase (MTHFR) is one of the most important enzymes for folate
metabolism. This enzyme is mapped on chromosome 1, which is located at the end of the …

Abstract Background Methylenetetrahydrofolate reductase (MTHFR) C677T and A1298C
polymorphisms have been implicated in childhood acute lymphoblastic leukemia (ALL) risk …

Purpose Fetal folate deficiency may increase the risk of subsequent childhood acute
leukemia (AL), since folates are required for DNA methylation, synthesis, and repair, but the …

Objective Folate is involved in the one-carbon metabolism that plays an essential role in the
synthesis, repair, and methylation of DNA. We examined whether child's germline genetic …

Abstract Background 5, 10-methylenetetrahydrofolate reductase (MTHFR) variants, C677T
and A1298C, have been reported to be associated with decreased risk of acute …

Objective The methylenetetrahydrofolate reductase gene C677T polymorphism is closely
related to the acute lymphoblastic leukemia. Several case–control studies have investigated …

The influence of genic polymorphisms involved in metabolism of chemotherapeutic agents
as the methotrexate (MTX) has been studied mainly in acute lymphoblastic leukemia (ALL) …