Rheumatic manifestations of chikungunya: emerging concepts and interventions

A Suhrbier - Nature Reviews Rheumatology, 2019 - nature.com
The largest epidemic ever recorded for chikungunya, a disease caused by infection with the
chikungunya virus (CHIKV), began in Africa in 2004 and spread to> 100 countries on four …

Epidemiology and economic burden of chikungunya: a systematic literature review

LB Costa, FKA Barreto, MCA Barreto… - Tropical Medicine and …, 2023 - mdpi.com
Chikungunya (CHIK) is a re-emerging viral infection endemic in tropical and subtropical
areas. While the typical clinical presentation is an acute febrile syndrome, long-term articular …

Enhanced attenuation of chikungunya vaccines expressing antiviral cytokines

C Chuong, C Cereghino, P Rai, TA Bates, M Oberer… - npj Vaccines, 2024 - nature.com
Alphaviruses are vector-borne, medically relevant, positive-stranded RNA viruses that cause
disease in animals and humans worldwide. Of this group, chikungunya virus (CHIKV) is the …

Current challenges in the discovery of treatments against Mayaro fever

RE Marques, JF Shimizu, ML Nogueira… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Mayaro fever is an emerging viral disease that manifests as an acute febrile
illness. The disease is self-limiting, however joint pain can persist for months leading to …

Insights into antibody-mediated alphavirus immunity and vaccine development landscape

A Torres-Ruesta, RSL Chee, LFP Ng - Microorganisms, 2021 - mdpi.com
Alphaviruses are mosquito-borne pathogens distributed worldwide in tropical and temperate
areas causing a wide range of symptoms ranging from inflammatory arthritis-like …

Autoinhibition of suicidal capsid protease from O'nyong'nyong virus

Y Chykunova, J Plewka, P Wilk, K Torzyk… - International Journal of …, 2024 - Elsevier
Alphaviruses pose a significant threat to public health. Capsid protein encoded in the
alphaviral genomes constitutes an interesting therapy target, as it also serves as a protease …

[HTML][HTML] Posaconazole inhibits multiple steps of the alphavirus replication cycle

FS Varghese, F Meutiawati, M Teppor, S Jacobs… - Antiviral research, 2022 - Elsevier
Repurposing drugs is a promising strategy to identify therapeutic interventions against novel
and re-emerging viruses. Posaconazole is an antifungal drug used to treat invasive …

A Rapid Assessment of Monkeypox: Is the Global Tourism and Hospitality Industry Ready for Another Havoc?

S Siddiqui, N Bano, Sujood - … of Quality Assurance in Hospitality & …, 2023 - Taylor & Francis
ABSTRACT The Tourism and Hospitality (T&H) industry and the entire world at large are still
recovering from the unprecedented impacts of the COVID-19 pandemic when incidents of …

Downregulation of CD73 on CD4+ T cells from patients with chronic chikungunya infection

PH de Sousa Palmeira, BM Gois, IC Guerra-Gomes… - Human Immunology, 2022 - Elsevier
Chikungunya is an important mosquito-borne disease caused by the arthritogenic
chikungunya virus, characterized by sporadic outbreaks all around the world. Although …

Bioprospection for new larvicides against Aedes aegypti based on ethnoknowledge from the Amazonian Sao Sebastiao de Marinau riverside community

PMC de Oliveira, JPB Sousa, LC Albernaz… - Journal of …, 2022 - Elsevier
Ethnopharmacological relevance Vector-borne diseases represent a huge global burden
impacting health systems. Aedes aegypti is the main vector of arboviral diseases including …