Depression is a polygenic and highly complex psychiatric disorder that remains a major
burden on society. Antidepressants, such as selective serotonin reuptake inhibitors (SSRIs) …

Serotonin modulates neuroplasticity, especially during early life, and dysfunctions in both
systems likewise contribute to pathophysiology of depression. Recent findings demonstrate …

ABSTRACT Introduction: Serotonin (5-HT) and brain-derived neurotrophic factor (BDNF) are
known as principal players in different kinds of plasticity. The 5-HT–BDNF interaction in early …

HT7 receptors (5-HT7R) are the most recently identified among the family of serotonin
receptors. Their role in health and disease, particularly as mediators of, and druggable …

Understanding the neurobiological underpinnings of depressive disorder constitutes a
pressing challenge in the fields of psychiatry and neurobiology. Depression represents one …

Neuronal events are regulated by the integration of several complex signaling networks in
which G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) are …

Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment
exits for them; likely as result of the absence of neural markers associated to memory …

Depression increasingly affects a wide range and a large number of people worldwide, both
physically and psychologically, which makes it a social problem requiring prompt attention …

It is well-documented that serotonin (5-HT) exerts its pharmacological effects through a
series of 5-HT receptors. The most recently identified member of this family, 5-HT7, was first …

The heteroreceptor complexes present a novel biological principle for signal integration.
These complexes and their allosteric receptor–receptor interactions are bidirectional and …