Although transcription is an essential cellular process, it is paradoxically also a well-
recognized cause of genomic instability. R-loops, non-B DNA structures formed when …

The UHRF protein family consists of multidomain regulatory proteins that sense modification
status of DNA and/or proteins and catalyze the ubiquitylation of target proteins. Through their …

Programmed constitutive heterochromatin silencing is essential for eukaryotic genome
regulation, yet the initial step of this process is ambiguous. A large proportion of R-loops …

Mutations of the SNF2 family ATPase HELLS and its activator CDCA7 cause
immunodeficiency, centromeric instability, and facial anomalies syndrome, characterized by …

Abstract HELLS/LSH (Helicase, Lymphoid Specific) is a SNF2-like chromatin remodelling
protein involved in DNA methylation. Its loss-of-function in humans causes humoral …

R-loops are atypical, three-stranded nucleic acid structures that contain a stretch of RNA:
DNA hybrids and an unpaired, single stranded DNA loop. R-loops are physiological relevant …

The maintenance of epigenetic characteristics is essential for the normal growth and
development of organisms. The maintenance of DNA methylation is an important way to …

Immunodeficiency, centromeric instability and facial anomalies (ICF) syndrome is in most
cases caused by mutations in either DNA methyltransferase (DNMT) 3B, zinc finger and BTB …

Tandemly repeated satellite DNAs are major components of centromeres and
pericentromeric heterochromatin which are crucial chromosomal elements responsible for …

Chromatin modifiers are emerging as major determinants of many types of cancers,
including Anaplastic Large Cell Lymphomas (ALCL), a family of highly heterogeneous T-cell …