Natural products for drug discovery in the 21st century: innovations for novel drug discovery

NE Thomford, DA Senthebane, A Rowe… - International journal of …, 2018 - mdpi.com
The therapeutic properties of plants have been recognised since time immemorial. Many
pathological conditions have been treated using plant-derived medicines. These medicines …

Melatonin supplementation during in vitro maturation of oocyte enhances subsequent development of bovine cloned embryos

Q An, W Peng, Y Cheng, Z Lu, C Zhou… - Journal of cellular …, 2019 - Wiley Online Library
Oocyte quality, which is directly related to reprogramming competence, is a major important
limiting factor in animal cloning efficiency. Compared with oocytes matured in vivo, in vitro …

Air pollution during pregnancy and placental adaptation in the levels of global DNA methylation

Z Maghbooli, A Hossein-Nezhad, E Adabi… - PLoS …, 2018 - journals.plos.org
Background Health in early life is crucial for health later in life. Exposure to air pollution
during embryonic and early-life development can result in placental epigenetic modification …

DNA methylation reprogramming during oogenesis and interference by reproductive technologies: studies in mouse and bovine models

E Anckaert, T Fair - Reproduction, Fertility and Development, 2015 - CSIRO Publishing
The use of assisted reproductive technology (ART) to overcome fertility problems has
continued to increase since the birth of the first baby conceived by ART over 30 years ago …

Genome-wide DNA methylation profiles changes associated with constant heat stress in pigs as measured by bisulfite sequencing

Y Hao, Y Cui, X Gu - Scientific Reports, 2016 - nature.com
Heat stress affects muscle development and meat quality in food animals; however, little is
known regarding its regulatory mechanisms at the epigenetic level, such as via DNA …

Genome-Wide DNA Methylation Patterns of Bovine Blastocysts Developed In Vivo from Embryos Completed Different Stages of Development In Vitro

D Salilew-Wondim, E Fournier, M Hoelker… - PloS one, 2015 - journals.plos.org
Early embryonic loss and altered gene expression in in vitro produced blastocysts are
believed to be partly caused by aberrant DNA methylation. However, specific embryonic …

[HTML][HTML] Evaluation of DNA methylation and mRNA expression of heat shock proteins in thermal manipulated chicken

A Vinoth, T Thirunalasundari, M Shanmugam… - Cell Stress and …, 2018 - Elsevier
Thermal manipulation during embryogenesis has been demonstrated to enhance the
thermotolerance capacity of broilers through epigenetic modifications. Heat shock proteins …

Comparative whole genome DNA methylation profiling across cattle tissues reveals global and tissue-specific methylation patterns

Y Zhou, S Liu, Y Hu, L Fang, Y Gao, H Xia… - BMC biology, 2020 - Springer
Background Efforts to improve animal health, and understand genetic bases for production,
may benefit from a comprehensive analysis of animal genomes and epigenomes. Although …

Comparative whole genome DNA methylation profiling of cattle sperm and somatic tissues reveals striking hypomethylated patterns in sperm

Y Zhou, EE Connor, DM Bickhart, C Li… - …, 2018 - academic.oup.com
Background Although sperm DNA methylation has been studied in humans and other
species, its status in cattle is largely unknown. Results Using whole-genome bisulfite …

Sequencing the mosaic genome of Brahman cattle identifies historic and recent introgression including polled

L Koufariotis, BJ Hayes, M Kelly, BM Burns, R Lyons… - Scientific reports, 2018 - nature.com
Brahman cattle have a Bos indicus and Bos taurus mosaic genome, as a result of the
process used to create the breed (repeat backcrossing of Bos taurus females to Bos indicus …