Challenges in developing personalized neoantigen cancer vaccines

PD Katsikis, KJ Ishii, C Schliehe - Nature Reviews Immunology, 2024 - nature.com
The recent success of cancer immunotherapies has highlighted the benefit of harnessing the
immune system for cancer treatment. Vaccines have a long history of promoting immunity to …

Regulation of cGAS-STING signalling in cancer: Approach for combination therapy

H Vasiyani, B Wadhwa, R Singh - … et Biophysica Acta (BBA)-Reviews on …, 2023 - Elsevier
Innate immunity plays an important role not only during infection but also homeostatic role
during stress conditions. Activation of the immune system including innate immune response …

cGAS‐STING pathway agonists are promising vaccine adjuvants

X Tian, J Ai, X Tian, X Wei - Medicinal Research Reviews, 2024 - Wiley Online Library
Adjuvants are of critical value in vaccine development as they act on enhancing
immunogenicity of antigen and inducing long‐lasting immunity. However, there are only a …

Immunotherapy with STING and TLR9 agonists promotes synergistic therapeutic efficacy with suppressed cancer-associated fibroblasts in colon carcinoma

S Hajiabadi, S Alidadi, Z Montakhab Farahi… - Frontiers in …, 2023 - frontiersin.org
The innate immune sensing of nucleic acids using effective immunoadjuvants is critical for
increasing protective immune responses against cancer. Stimulators of interferon genes …

TLR9 plus STING Agonist Adjuvant Combination Induces Potent Neopeptide T Cell Immunity and Improves Immune Checkpoint Blockade Efficacy in a Tumor Model

MD Castro Eiro, K Hioki, L Li, MEP Wilmsen… - The Journal of …, 2024 - journals.aai.org
Immune checkpoint blockade (ICB) immunotherapies have emerged as promising strategies
for the treatment of cancer; however, there remains a need to improve their efficacy …

Pattern recognition receptors and their nano-adjuvants for cancer immunotherapy

Z Li, I Rana, G Park, J Lee, CE Park, J Nam - Journal of Pharmaceutical …, 2023 - Springer
Abstract Background Pattern recognition receptors (PRRs) are crucial immune modulators
that orchestrate innate and adaptive immune systems for the regulation of inflammatory …

Toll-like receptor 9 agonists and combination therapies: strategies to modulate the tumour immune microenvironment for systemic anti-tumour immunity

Z Dongye, J Li, Y Wu - British Journal of Cancer, 2022 - nature.com
Over the past decade, tremendous progress has taken place in tumour immunotherapy,
relying on the fast development of combination therapy strategies that target multiple …

Cytosolic bacterial pathogens activate TLR pathways in tumors that synergistically enhance STING agonist cancer therapies

M Danielson, CJ Nicolai, TT Vo, NK Wolf, TP Burke - iScience, 2024 - cell.com
Intracellular bacterial pathogens are distinctive tools for fighting cancer, as they can
proliferate in tumors and deliver therapeutic payloads to the eukaryotic cytosol. Cytosol …

[HTML][HTML] Cooperative tumor inhibition by CpG-oligodeoxynucleotide and cyclic dinucleotide in head and neck cancer involves T helper cytokine and macrophage …

ZN Imana, JC Tseng, JX Yang, YL Liu, PY Lin… - Biomedicine & …, 2024 - Elsevier
Head and neck cancer ranks as the sixth most common cancer worldwide, highlighting the
critical need for the development of new therapies to enhance treatment efficacy. The …

DNA Nanostructures‐Based In Situ Cancer Vaccines: Mechanisms and Applications

B Lin, Y Liu, Q Chen, M Li, L Xu, Q Chen, Y Tan… - Small …, 2025 - Wiley Online Library
Current tumor vaccines suffer from inadequate immune responsive due to the insufficient
release of tumor antigens, low tumor infiltration, and immunosuppressive microenvironment …