Identifying recent HIV infections: from serological assays to genomics
In this paper, we review serological and molecular based methods to identify HIV infection
recency. The accurate identification of recent HIV infection continues to be an important …
recency. The accurate identification of recent HIV infection continues to be an important …
Inferring the multiplicity of founder variants initiating HIV-1 infection: a systematic review and individual patient data meta-analysis
Background HIV-1 infections initiated by multiple founder variants are characterised by a
higher viral load and a worse clinical prognosis than those initiated with single founder …
higher viral load and a worse clinical prognosis than those initiated with single founder …
Intercompartmental Recombination of HIV-1 Contributes to env Intrahost Diversity and Modulates Viral Tropism and Sensitivity to Entry Inhibitors
RJP Brown, PJ Peters, C Caron… - Journal of …, 2011 - Am Soc Microbiol
ABSTRACT HIV-1 circulates within an infected host as a genetically heterogeneous viral
population. Viral intrahost diversity is shaped by substitutional evolution and recombination …
population. Viral intrahost diversity is shaped by substitutional evolution and recombination …
Extended high viremics: a substantial fraction of individuals maintain high plasma viral RNA levels after acute HIV-1 subtype C infection
Objective: The present study addressed two questions: what fraction of individuals maintain
a sustained high HIV-1 RNA load after the acute HIV-1C infection peak and how long is a …
a sustained high HIV-1 RNA load after the acute HIV-1C infection peak and how long is a …
HIV-1 subtype C-infected individuals maintaining high viral load as potential targets for the “test-and-treat” approach to reduce HIV transmission
The first aim of the study is to assess the distribution of HIV-1 RNA levels in subtype C
infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in …
infection. Among 4,348 drug-naïve HIV-positive individuals participating in clinical studies in …
Long-range HIV genotyping using viral RNA and proviral DNA for analysis of HIV drug resistance and HIV clustering
V Novitsky, M Zahralban-Steele… - Journal of clinical …, 2015 - Am Soc Microbiol
The goal of the study was to improve the methodology of HIV genotyping for analysis of HIV
drug resistance and HIV clustering. Using the protocol of Gall et al.(A. Gall, B. Ferns, C …
drug resistance and HIV clustering. Using the protocol of Gall et al.(A. Gall, B. Ferns, C …
Phylogenetic relatedness of circulating HIV-1C variants in Mochudi, Botswana
Background Determining patterns of HIV transmission is increasingly important for the most
efficient use of modern prevention interventions. HIV phylogeny can provide a better …
efficient use of modern prevention interventions. HIV phylogeny can provide a better …
Transmission of single and multiple viral variants in primary HIV-1 subtype C infection
V Novitsky, R Wang, L Margolin, J Baca… - PLoS …, 2011 - journals.plos.org
To address whether sequences of viral gag and env quasispecies collected during the early
post-acute period can be utilized to determine multiplicity of transmitted HIV's, recently …
post-acute period can be utilized to determine multiplicity of transmitted HIV's, recently …
[HTML][HTML] Nef-mediated down-regulation of CD4 and HLA class I in HIV-1 subtype C infection: association with disease progression and influence of immune pressure
Nef plays a major role in HIV-1 pathogenicity. We studied HIV-1 subtype C infected
individuals in acute/early (n= 120) or chronic (n= 207) infection to investigate the …
individuals in acute/early (n= 120) or chronic (n= 207) infection to investigate the …
Intra-host evolutionary rates in HIV-1C env and gag during primary infection
Background HIV-1 nucleotide substitution rates are central for understanding the evolution
of HIV-1. Their accurate estimation is critical for analysis of viral dynamics, identification of …
of HIV-1. Their accurate estimation is critical for analysis of viral dynamics, identification of …