The PEP-pyruvate-oxaloacetate node: variation at the heart of metabolism
JG Koendjbiharie, R Van Kranenburg… - FEMS microbiology …, 2021 - academic.oup.com
At the junction between the glycolysis and the tricarboxylic acid cycle—as well as various
other metabolic pathways—lies the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate …
other metabolic pathways—lies the phosphoenolpyruvate (PEP)-pyruvate-oxaloacetate …
Circadian rhythms in cardiovascular metabolism
Energetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …
with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour …
[HTML][HTML] Branched chain amino acids selectively promote cardiac growth at the end of the awake period
MN Latimer, R Sonkar, S Mia, IR Frayne… - Journal of molecular and …, 2021 - Elsevier
Essentially all biological processes fluctuate over the course of the day, manifesting as time-
of-day-dependent variations with regards to the way in which organ systems respond to …
of-day-dependent variations with regards to the way in which organ systems respond to …
Genetic disruption of the cardiomyocyte circadian clock differentially influences insulin-mediated processes in the heart
Cardiovascular physiology exhibits time-of-day-dependent oscillations, which are mediated
by both extrinsic (eg, environment/behavior) and intrinsic (eg, circadian clock) factors …
by both extrinsic (eg, environment/behavior) and intrinsic (eg, circadian clock) factors …
Differential effects of REV-ERBα/β agonism on cardiac gene expression, metabolism, and contractile function in a mouse model of circadian disruption
Cell-autonomous circadian clocks have emerged as temporal orchestrators of numerous
biological processes. For example, the cardiomyocyte circadian clock modulates …
biological processes. For example, the cardiomyocyte circadian clock modulates …
Circadian regulation of cardiac physiology: rhythms that keep the heart beating
J Zhang, JC Chatham, ME Young - Annual review of physiology, 2020 - annualreviews.org
On Earth, all life is exposed to dramatic changes in the environment over the course of the
day; consequently, organisms have evolved strategies to both adapt to and anticipate these …
day; consequently, organisms have evolved strategies to both adapt to and anticipate these …
Integration of melatonin related redox homeostasis, aging, and circadian rhythm
Circadian rhythms (CRs) are intrinsic clocks organizing the behavior and physiology of
organisms. These clocks are thought to have coevolved with cellular redox regulation …
organisms. These clocks are thought to have coevolved with cellular redox regulation …
Temporal partitioning of cardiac metabolism by the cardiomyocyte circadian clock
ME Young - Experimental physiology, 2016 - Wiley Online Library
New Findings What is the topic of this review? This review highlights temporal partitioning of
cardiac metabolism by the cardiomyocyte circadian clock. What advances does it highlight …
cardiac metabolism by the cardiomyocyte circadian clock. What advances does it highlight …
Dense time-course gene expression profiling of the Drosophila melanogaster innate immune response
Background Immune responses need to be initiated rapidly, and maintained as needed, to
prevent establishment and growth of infections. At the same time, resources need to be …
prevent establishment and growth of infections. At the same time, resources need to be …
Coordination of cardiac rhythmic output and circadian metabolic regulation in the heart
Over the course of a 24-h day, demand on the heart rises and falls with the sleep/wake
cycles of the organism. Cardiac metabolism oscillates appropriately, with the relative …
cycles of the organism. Cardiac metabolism oscillates appropriately, with the relative …