Isoniazid–phytochemical conjugation: A new approach for potent and less toxic anti‐TB drug development

SS Swain, SK Paidesetty, RN Padhy… - Chemical Biology & …, 2020 - Wiley Online Library
Mycobacterium tuberculosis (Mtb) causes one of the most grievous pandemic infectious
diseases, tuberculosis (TB), with long‐term morbidity and high mortality. The emergence of …

Identification of pyrazole derivatives of usnic acid as novel inhibitor of SARS-CoV-2 main protease through virtual screening approaches

M Roney, G Singh, AKMM Huq, MS Forid… - Molecular …, 2024 - Springer
The infection produced by the SARS-CoV-2 virus remains a significant health crisis
worldwide. The lack of specific medications for COVID-19 necessitates a concerted effort to …

Bioactivities and Structure-Activity Relationships of Usnic Acid Derivatives: A Review

WZ Nie, QK Shen, ZS Quan, HY Guo… - Mini Reviews in …, 2024 - ingentaconnect.com
Usnic acid has a variety of biological activities, and has been widely studied in the fields of
antibacterial, immune stimulation, antiviral, antifungal, anti-inflammatory and antiparasitic …

Phenylisoxazole‐3/5‐Carbaldehyde Isonicotinylhydrazone Derivatives: Synthesis, Characterization, and Antitubercular Activity

F Carrasco, W Hernández, O Chupayo… - Journal of …, 2021 - Wiley Online Library
Eight new phenylisoxazole isoniazid derivatives, 3‐(2′‐fluorophenyl) isoxazole‐5‐
carbaldehyde isonicotinylhydrazone (1), 3‐(2′‐methoxyphenyl) isoxazole‐5‐carbaldehyde …

Synthesis and antimycobacterial activity of (+)‐usnic acid conjugates

D Cirillo, E Borroni, I Festoso, D Monti… - Archiv der …, 2018 - Wiley Online Library
New therapeutics are urgently needed to fight tuberculosis and mycobacteria‐related
diseases that are a major health hazard especially in poor countries. Natural products have …

[HTML][HTML] Artículo de revisión. Ácido úsnico: alternativa potencial contra la resistencia bacteriana actual

SJ Avila-Zamora, YD Pinzon-Perez… - Revista Tecnología en …, 2023 - scielo.sa.cr
El ácido úsnico (AU) es una sustancia liquénica, que hace parte de los metabolitos
secundarios de los líquenes, los cuales son organismos que generan una simbiosis entre …

[HTML][HTML] Usnic acid: potential alternative against current bacterial resistance

SJ Avila-Zamora, YD Pinzon-Perez… - Revista Tecnología en …, 2023 - scielo.sa.cr
El ácido úsnico (AU) es una sustancia liquénica, que hace parte de los metabolitos
secundarios de los líquenes, los cuales son organismos que generan una simbiosis entre …

[HTML][HTML] Pyrazinamide-isoniazid hybrid: synthesis optimisation, characterisation, and antituberculous activity

RI Ramírez Panti, CM Aliaga Paucar… - Revista Colombiana …, 2021 - scielo.org.co
Over time, the effective resistance mechanisms to various first-and second-line drugs
against the disease of tuberculosis make its treatment extremely difficult. This work presents …

Isolation and structural elucidation of a new depside of lichen Everniopsis trulla

ON Castro, JL Rodilla, S Pombal… - Revista de la …, 2021 - revistas.sqperu.org.pe
En esta investigación se ha aislado a un nuevo dépsido del liquen Everniopsis trulla. Se
realizó la extracción a 400 g de muestra seca y molida con etanol por 3 repeticiones, luego …

[PDF][PDF] Híbrido pirazinamida-isonia-cida: optimización de sínte-sis, caracterización y activi-dad antituberculosa

RIR Panti, CMA Paucar, FG Arias… - Revista Colombiana …, 2021 - researchgate.net
Debido a los grandes mecanismos de resistencia a lo largo del tiempo de diversos
fármacos de primera y segunda línea contra la enfermedad de la tuberculosis, el tratamiento …