Novel noninvasive approaches to the treatment of obesity: from pharmacotherapy to gene therapy

AM Angelidi, MJ Belanger, A Kokkinos… - Endocrine …, 2022 - academic.oup.com
Recent insights into the pathophysiologic underlying mechanisms of obesity have led to the
discovery of several promising drug targets and novel therapeutic strategies to address the …

The implication of gut hormones in the regulation of energy homeostasis and their role in the pathophysiology of obesity

C Koliaki, S Liatis, M Dalamaga, A Kokkinos - Current obesity reports, 2020 - Springer
Abstract Purpose of Review This review provides an update on the role of gut hormones and
their interactions in the regulation of energy homeostasis, describes gut hormone …

Do gut hormones contribute to weight loss and glycaemic outcomes after bariatric surgery?

D Papamargaritis, CW le Roux - Nutrients, 2021 - mdpi.com
Bariatric surgery is an effective intervention for management of obesity through treating
dysregulated appetite and achieving long-term weight loss maintenance. Moreover …

Nutritional deficiencies before and after bariatric surgery: prevention and treatment

G Argyrakopoulou, SK Konstantinidou… - Current Nutrition …, 2022 - Springer
Abstract Purpose of Review Bariatric surgery has the unique ability to drive substantial and
sustainable weight loss in people living with obesity. Non-reversibility of these surgical …

Pleurotus eryngii improves postprandial glycaemia, hunger and fullness perception, and enhances ghrelin suppression in people with metabolically unhealthy obesity

SA Kleftaki, S Simati, C Amerikanou, A Gioxari… - Pharmacological …, 2022 - Elsevier
The aim of this study was to examine potential postprandial benefits of Pleurotus eryngii in
nineteen volunteers with metabolically unhealthy obesity. An acute, randomized, crossover …

Advances in physiology, design and development of novel medications changing the landscape of obesity pharmacotherapy

M Chakhtoura, CS Mantzoros - Metabolism-Clinical and …, 2023 - metabolismjournal.com
As the word has been celebrating innovations and technological achievements during the
last few decades, there has also been a noticeable increase in various non-communicable …

[HTML][HTML] Alliances of the gut and bone axis

MS Hansen, M Frost - Seminars in Cell & Developmental Biology, 2022 - Elsevier
Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate
metabolic processes including glucose homeostasis and food intake, and several of these …

Factors affecting weight loss variability in obesity

R Dent, R McPherson, ME Harper - Metabolism, 2020 - Elsevier
Current obesity treatment strategies include diet, exercise, bariatric surgery, and a limited
but growing repertoire of medications. Individual weight loss in response to each of these …

The role of glicentin and oxyntomodulin in human metabolism: new evidence and new directions

N Perakakis, CS Mantzoros - The Journal of Clinical …, 2020 - academic.oup.com
Posttranslational processing of proglucagon leads to the formation of glucagon-like peptide-
1 (GLP-1), oxyntomodulin, and glicentin, which are secreted by enteroendocrine L-cells, and …

Are the changes in gastrointestinal hormone secretion necessary for the success of bariatric surgery? A critical review of the literature

C Lampropoulos, T Alexandrides, S Tsochatzis… - Obesity Surgery, 2021 - Springer
Abstract Ghrelin, glucagon-like peptide-1 (GLP-1), and peptide YY (PYY) are involved in
energy balance regulation and glucose homeostasis. Obesity is characterized by lower …