Melatonin: roles in influenza, Covid‐19, and other viral infections

G Anderson, RJ Reiter - Reviews in medical virology, 2020 - Wiley Online Library
There is a growing appreciation that the regulation of the melatonergic pathways, both
pineal and systemic, may be an important aspect in how viruses drive the cellular changes …

[HTML][HTML] Perfect timing: circadian rhythms, sleep, and immunity—an NIH workshop summary

JA Haspel, R Anafi, MK Brown, N Cermakian… - JCI insight, 2020 - ncbi.nlm.nih.gov
Recent discoveries demonstrate a critical role for circadian rhythms and sleep in immune
system homeostasis. Both innate and adaptive immune responses—ranging from leukocyte …

Circadian rhythms, disease and chronotherapy

Y Lee, JM Field, A Sehgal - Journal of biological rhythms, 2021 - journals.sagepub.com
Circadian clocks are biological timing mechanisms that generate 24-h rhythms of physiology
and behavior, exemplified by cycles of sleep/wake, hormone release, and metabolism. The …

[HTML][HTML] Molecular clock REV-ERBα regulates cigarette smoke–induced pulmonary inflammation and epithelial-mesenchymal transition

Q Wang, IK Sundar, JH Lucas, T Muthumalage… - JCI insight, 2021 - ncbi.nlm.nih.gov
Cigarette smoke (CS) is the main etiological factor in the pathogenesis of
emphysema/chronic obstructive pulmonary disease (COPD), which is associated with …

The genomic basis of temporal niche evolution in a diurnal rodent

R Richardson, CY Feigin, B Bano-Otalora, MR Johnson… - Current Biology, 2023 - cell.com
Patterns of diel activity—how animals allocate their activity throughout the 24-h daily cycle—
play key roles in shaping the internal physiology of an animal and its relationship with the …

Circadian rhythms in innate immunity and stress responses

M Baxter, DW Ray - Immunology, 2020 - Wiley Online Library
Circadian clocks are a common feature of life on our planet, allowing physiology and
behaviour to be adapted to recurrent environmental fluctuation. There is now compelling …

The circadian clock component BMAL1 regulates SARS-CoV-2 entry and replication in lung epithelial cells

X Zhuang, S Tsukuda, F Wrensch, PAC Wing… - IScience, 2021 - cell.com
The coronavirus disease 2019 pandemic, caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) coronavirus, is a global health issue with unprecedented …

The circadian clock, the immune system, and viral infections: the intricate relationship between biological time and host-virus interaction

G Mazzoccoli, M Vinciguerra, A Carbone, A Relógio - Pathogens, 2020 - mdpi.com
Living beings spend their lives and carry out their daily activities interacting with
environmental situations that present space-time variations and that involve contact with …

The circadian clock and inflammation: A new insight

H Xu, L Huang, J Zhao, S Chen, J Liu, G Li - Clinica Chimica Acta, 2021 - Elsevier
The circadian clock is a complex cellular mechanism that controls a series of physiological
processes, including inflammation. It can directly interact physically with the components of …

Why lungs keep time: circadian rhythms and lung immunity

C Nosal, A Ehlers, JA Haspel - Annual review of physiology, 2020 - annualreviews.org
Circadian rhythms are daily cycles in biological function that are ubiquitous in nature.
Understood as a means for organisms to anticipate daily environmental changes, circadian …