Parkinson's disease (PD) is a progressive movement disorder resulting primarily from loss of
nigrostriatal dopaminergic neurons. PD is characterized by the accumulation of protein …

Conditions including heating mode, time, temperature, pH, moisture and protein
concentration, shear, and the presence of alcohols, chaotropic/reducing agents, enzymes …

Protein aggregation and subsequent accumulation of insoluble amyloid fibrils with cross-β
structure is an intrinsic characteristic of amyloid diseases, ie, amyloidoses. Amyloid …

Introduction Protein aggregation and deposition of uniformly arranged amyloid fibrils in the
form of plaques or amorphous aggregates is characteristic of amyloid diseases. The …

Protein misfolding and aggregation are associated with several human diseases such as
Alzheimer's, Parkinson's, prion related disorders, type-II diabetes, etc. Different strategies …

Amyloid fibrils are the hallmarks of neurodegenerative diseases like Alzheimer's,
Parkinson's and other proteopathies. Inhibition of fibrillation is a potential strategy to check …

Intrinsically disordered proteins (IDPs) and intrinsically disordered protein regions (IDPRs)
are proteins and protein segments that usually do not acquire well-defined folded structures …

Inhibition of highly ordered cross-β-sheet-rich aggregates of misfolded amyloid proteins
using rationally designed sequence-based short peptides is a promising therapeutic …

Lysozyme, a well-known bacteriolytic enzyme, exhibits a fascinating yet complex behavior
when it comes to protein aggregation. Under certain conditions, this enzyme undergoes …

Protein misfolding diseases are associated with human pathologies. These
neurodegenerative diseases remain challenging task for researchers because of their …