Topological features of rugged fitness landscapes in sequence space
DA Kondrashov, FA Kondrashov - Trends in Genetics, 2015 - cell.com
The factors that determine the tempo and mode of protein evolution continue to be a central
question in molecular evolution. Traditionally, studies of protein evolution focused on the …
question in molecular evolution. Traditionally, studies of protein evolution focused on the …
Changing preferences: deformation of single position amino acid fitness landscapes and evolution of proteins
GA Bazykin - Biology letters, 2015 - royalsocietypublishing.org
The fitness landscape—the function that relates genotypes to fitness—and its role in
directing evolution are a central object of evolutionary biology. However, its huge …
directing evolution are a central object of evolutionary biology. However, its huge …
Epistasis and the dynamics of reversion in molecular evolution
Recent studies of protein evolution contend that the longer an amino acid substitution is
present at a site, the less likely it is to revert to the amino acid previously occupying that site …
present at a site, the less likely it is to revert to the amino acid previously occupying that site …
A model of substitution trajectories in sequence space and long-term protein evolution
DR Usmanova, L Ferretti… - Molecular biology …, 2014 - academic.oup.com
The nature of factors governing the tempo and mode of protein evolution is a fundamental
issue in evolutionary biology. Specifically, whether or not interactions between different …
issue in evolutionary biology. Specifically, whether or not interactions between different …