Overview of strategies to improve therapy against tumors using natural killer cell

C Yang, Y Li, Y Yang, Z Chen - Journal of Immunology …, 2020 - Wiley Online Library
NK cells are lymphocytes with antitumor properties and can directly lyse tumor cells in a non‐
MHC‐restricted manner. However, the tumor microenvironment affects the immune function …

Natural killer cells: a future star for immunotherapy of head and neck squamous cell carcinoma

S Dong, M Zhao, J Zhu, T Li, M Yan, K Xing… - Frontiers in …, 2024 - frontiersin.org
The interplay between immune components and the epithelium plays a crucial role in the
development and progression of head and neck squamous cell carcinoma (HNSCC) …

KIR-HLA gene diversities and susceptibility to lung cancer

M Hematian Larki, E Ashouri, S Barani… - Scientific Reports, 2022 - nature.com
Killer-cell immunoglobulin-like receptors (KIR) are essential for acquiring natural killer (NK)
cell effector function, which is modulated by a balance between the net input of signals …

Coexistence of inhibitory and activating killer-cell immunoglobulin-like receptors to the same cognate HLA-C2 and Bw4 ligands confer breast cancer risk

E Ashouri, K Rajalingam, S Barani, S Farjadian… - Scientific reports, 2021 - nature.com
Human leukocyte antigen (HLA) class I-specific killer-cell immunoglobulin-like receptors
(KIR) regulate natural killer (NK) cell function in eliminating malignancy. Breast cancer (BC) …

Activating and inhibitory killer cell immunoglobulin like receptors (KIR) genes are involved in an increased susceptibility to colorectal adenocarcinoma and protection …

S Barani, SV Hosseini, A Ghaderi - Immunobiology, 2019 - Elsevier
Background: A set of activating and inhibitory KIRs (aKIR, iKIR) are involved in NK cell
mediated immunity. This study was carried out in order to investigate the KIRs pattern and its …

Development of cost‐effective and fast KIR genotyping by multiplex PCR‐SSP

EJ Choi, IC Baek, S Park, HJ Kim, TG Kim - Hla, 2024 - Wiley Online Library
Killer‐cell immunoglobulin‐like receptors (KIR) control natural killer (NK) cell functions by
recognizing HLA molecules and modulating the activity of NK cells. The KIR gene cluster …

Diversity of KIRs in invasive breast cancer patients and healthy controls along with the clinical significance in ER/PR/HER2+ patients

M Hematian Larki, S Barani, AR Talei, A Ghaderi - Genes & Immunity, 2020 - nature.com
Killer cell immunoglobulin-like receptors (KIR) consists of activating and inhibitory genes are
essential for natural killer cell education. To determine the association of KIR s with …

The effects of killer cell immunoglobulin-like receptor (KIR) genes on susceptibility to severe COVID-19 in the Iranian population

N Karami, S Barani, M Fani, S Meri, R Shafiei… - BMC immunology, 2024 - Springer
Background Variations in the innate and adaptive immune response systems are linked to
variations in the severity of COVID-19. Natural killer cell (NK) function is regulated by …

Evaluation of the genetic diversity of KIR genes in patients with endometrial cancer

Z Shiravani, K Mirshekari, MH Larki, N Shafiee… - Journal of Reproductive …, 2024 - Elsevier
Endometrial cancer (EC) constitutes more than half of all genital cancers in women, with an
increasing incidence in different countries. Natural killer cells (NK cells) are kinds of innate …

Combination of KIR2DS4 and FcγRIIa polymorphisms predicts the response to cetuximab in KRAS mutant metastatic colorectal cancer

A Borrero-Palacios, A Cebrián, MT Gómez Del Pulgar… - Scientific reports, 2019 - nature.com
Cetuximab is a standard-of-care treatment for RAS wild-type metastatic colorectal cancer
(mCRC) but not for those harbor a KRAS mutation since MAPK pathway is constitutively …