The biology of F-box proteins: the SCF family of E3 ubiquitin ligases

KM Nguyen, L Busino - Cullin-RING Ligases and Protein Neddylation …, 2020 - Springer
F-box proteins function as substrate adaptors for the S-phase kinase-associated protein 1
(SKP1)-cullin 1 (CUL1)-F-box protein (SCF) ubiquitin ligase complexes, which mediate the …

[HTML][HTML] F-box proteins and cancer: an update from functional and regulatory mechanism to therapeutic clinical prospects

DS Tekcham, D Chen, Y Liu, T Ling, Y Zhang… - Theranostics, 2020 - ncbi.nlm.nih.gov
E3 ubiquitin ligases play a critical role in cellular mechanisms and cancer progression. F-
box protein is the core component of the SKP1-cullin 1-F-box (SCF)-type E3 ubiquitin ligase …

[HTML][HTML] F-box protein interactions with the hallmark pathways in cancer

SJ Randle, H Laman - Seminars in Cancer Biology, 2016 - Elsevier
F-box proteins (FBP) are the substrate specifying subunit of Skp1-Cul1-FBP (SCF)-type E3
ubiquitin ligases and are responsible for directing the ubiquitination of numerous proteins …

Circular RNA circRNA_103809 accelerates bladder cancer progression and enhances chemo-resistance by activation of miR-516a-5p/FBXL18 Axis

W Huang, Y Lu, F Wang, X Huang… - Cancer management and …, 2020 - Taylor & Francis
Background Numerous researches have suggested that circular RNAs (circRNAs) play
critical functions in bladder cancer (BC) progression. This study aims to investigate the …

Genetics of Alzheimer's disease: the importance of polygenic and epistatic components

N Raghavan, G Tosto - Current neurology and neuroscience reports, 2017 - Springer
Abstract Purpose of Review We aimed to summarize the recent advances in genetic findings
of Alzheimer's disease (AD), focusing on traditional single-marker and gene approaches …

Genome-wide association analysis for β-hydroxybutyrate concentration in Milk in Holstein dairy cattle

S Nayeri, F Schenkel, A Fleming, V Kroezen… - BMC genetics, 2019 - Springer
Background Ketosis in dairy cattle has been shown to cause a high morbidity in the farm and
substantial financial losses to dairy farmers. Ketosis symptoms, however, are difficult to …

Ubiquitination-mediated degradation of cell cycle-related proteins by F-box proteins

N Zheng, Z Wang, W Wei - The International Journal of Biochemistry & Cell …, 2016 - Elsevier
F-box proteins, subunits of SKP1-cullin 1-F-box protein (SCF) type of E3 ubiquitin ligase
complexes, have been validated to play a crucial role in governing various cellular …

The proapoptotic F-box protein Fbxl7 regulates mitochondrial function by mediating the ubiquitylation and proteasomal degradation of survivin

Y Liu, T Lear, O Iannone, S Shiva, C Corey… - Journal of Biological …, 2015 - ASBMB
Fbxl7, a component of the Skp1· Cul1· F-box protein type ubiquitin E3 ligase, regulates
mitotic cell cycle progression. Here we demonstrate that overexpression of Fbxl7 in lung …

Functional characterization of FBXL7 as a novel player in human cancers

Y Wang, X Shen, L Gong, Y Zhao, X Xiong - Cell death discovery, 2022 - nature.com
F-box and leucine-rich repeat protein 7 (FBXL7), an F-box protein responsible for substrate
recognition by the SKP1-Cullin-1-F-box (SCF) ubiquitin ligases, plays an emerging role in …

Genetic associations of the response to inhaled corticosteroids in asthma: a systematic review

O Keskin, N Farzan, E Birben, H Akel… - Clinical and …, 2019 - Wiley Online Library
There is wide variability in the response to inhaled corticosteroids (ICS) in asthma. While
some of this heterogeneity of response is due to adherence and environmental causes …