The cerebellum is involved in sensorimotor operations, cognitive tasks and affective
processes. Here, we revisit the concept of the cerebellar syndrome in the light of recent …

Background We assessed the clinimetric properties of ataxia rating scales and functional
tests, and made recommendations regarding their use. Methods A systematic literature …

Ataxia due to an autosomal dominant intronic GAA repeat expansion in FGF14 [GAA-FGF14
ataxia, spinocerebellar ataxia 27B (SCA27B)] has recently been identified as one of the …

Background Spinocerebellar ataxias are dominantly inherited neurodegenerative diseases.
As potential treatments for these diseases are being developed, precise knowledge of their …

Background Friedreich's ataxia is a rare autosomal recessive neurodegenerative disorder.
Here we report cross-sectional baseline data to establish the biological and clinical …

Summary Background Spinocerebellar ataxias (SCAs) are autosomal, dominantly inherited,
fully penetrant neurodegenerative diseases. Our aim was to study the preclinical stage of the …

Background Riluzole has been reported to be beneficial in patients with cerebellar ataxia;
however, effectiveness in individual subtypes of disease is unclear due to heterogeneity in …

Repeated sessions of cerebellar anodal transcranial direct current stimulation (tDCS) have
been suggested to modulate cerebellar-motor cortex (M1) connectivity and decrease ataxia …

Background and purpose Clinical trials in spinocerebellar ataxia type 3 (SCA3) will require
biomarkers for use as outcome measures. Methods To evaluate total tau (t‐tau), glial …

Background GAA-FGF14 disease/spinocerebellar ataxia 27B is a recently described
neurodegenerative disease caused by (GAA)≥ 250 expansions in the fibroblast growth …