The genomes of prokaryotes and eukaryotic organelles are usually circular as are most
plasmids and viral genomes. In contrast, the nuclear genomes of eukaryotes are organized …

The telomeres that cap the ends of eukaryotic chromosomes serve a dual role in protecting
the chromosome ends and in intracellular signaling for regulating cell proliferation. A …

The terminal t-loop structure adopted by mammalian telomeres is thought to prevent
telomeres from being recognized as double-stranded DNA breaks by sequestering the 3 …

Orthologs of the yeast telomere protein Stn1 are present in plants, but other components of
the Cdc13/Stn1/Ten1 (CST) complex have only been found in fungi. Here we report the …

Meiosis is essential for eukaryotic sexual reproduction, with two consecutive rounds of
nuclear divisions, allowing production of haploid gametes. Information regarding the meiotic …

The single-stranded telomeric DNA binding protein POT1 protects mammalian chromosome
ends from the ATR-dependent DNA damage response, regulates telomerase-mediated …

In the absence of functional telomeric cap protection, the ends of eukaryotic chromosomes
are subject to DNA damage responses that lead to cell-cycle arrest and, eventually, genomic …

Human shelterin components POT1 and TPP1 form a stable heterodimer that protects
telomere ends from ATR-dependent DNA damage responses and regulates telomerase …

POT1 (p rotection oft elomere 1) is a highly conserved single‐stranded telomeric binding
protein that is essential for telomere end protection. Here, we report the cloning and …

The six human telomeric proteins TRF1, TRF2, RAP1, TIN2, POT1, and TPP1 can form a
complex called the telosome/shelterin, which is required for telomere protection and length …