Kidney fibrosis: from mechanisms to therapeutic medicines
R Huang, P Fu, L Ma - Signal Transduction and Targeted Therapy, 2023 - nature.com
Chronic kidney disease (CKD) is estimated to affect 10–14% of global population. Kidney
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
fibrosis, characterized by excessive extracellular matrix deposition leading to scarring, is a …
[HTML][HTML] Lysyl oxidases: Emerging biomarkers and therapeutic targets for various diseases
Therapeutic targeting of extracellular proteins has attracted huge attention in treating human
diseases. The lysyl oxidases (LOXs) are a family of secreted copper-dependent enzymes …
diseases. The lysyl oxidases (LOXs) are a family of secreted copper-dependent enzymes …
Pan-lysyl oxidase inhibitor PXS-5505 ameliorates multiple-organ fibrosis by inhibiting collagen crosslinks in rodent models of systemic sclerosis
Systemic sclerosis (SSc) is characterised by progressive multiple organ fibrosis leading to
morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and …
morbidity and mortality. Lysyl oxidases play a vital role in the cross-linking of collagens and …
Ferulic acid ameliorates the progression of pulmonary fibrosis via inhibition of TGF-β/smad signalling
Natural products are one of the best sources for the discovery of novel drugs and
compounds for multiple diseases. Pulmonary fibrosis (PF) is a chronic, progressive …
compounds for multiple diseases. Pulmonary fibrosis (PF) is a chronic, progressive …
Piperlongumine attenuates bile duct ligation-induced liver fibrosis in mice via inhibition of TGF-β1/Smad and EMT pathways
Liver fibrosis (LF) is a progressive liver injury that may result in excessive accumulation of
extracellular matrix (ECM). However, transforming growth factor-beta (TGF-β) and epithelial …
extracellular matrix (ECM). However, transforming growth factor-beta (TGF-β) and epithelial …
Nimbolide ameliorates pancreatic inflammation and apoptosis by modulating NF-κB/SIRT1 and apoptosis signaling in acute pancreatitis model
Acute pancreatitis (AP) is a potential gastrointestinal problem most commonly associated
with pancreatic inflammation and acinar cells injury. Nimbolide (NB), isolated from the tree …
with pancreatic inflammation and acinar cells injury. Nimbolide (NB), isolated from the tree …
COVID-19 and fibrosis: Mechanisms, clinical relevance, and future perspectives
Highlights•The development of fibrosis in COVID-19 survivors is a major concern.•Although,
the fibrosis is resolved over time, there is a concern of residual effects of viral infection in the …
the fibrosis is resolved over time, there is a concern of residual effects of viral infection in the …
Silibinin alleviates silica‐induced pulmonary fibrosis: Potential role in modulating inflammation and epithelial‐mesenchymal transition
Pulmonary fibrosis (PF) is a devastating interstitial lung disease resulting from indefinite
causes with very few limited, those too ineffective therapeutic options. Earlier evidence …
causes with very few limited, those too ineffective therapeutic options. Earlier evidence …
Impact of high-molecular-weight hyaluronic acid on gene expression in rabbit achilles tenocytes in vitro
I Miescher, P Wolint, C Opelz, JG Snedeker… - International Journal of …, 2022 - mdpi.com
(1) Background: Surgical tendon repair often leads to adhesion formation, leading to joint
stiffness and a reduced range of motion. Tubular implants set around sutured tendons might …
stiffness and a reduced range of motion. Tubular implants set around sutured tendons might …
A direct thrombin inhibitor, dabigatran etexilate protects from renal fibrosis by inhibiting protease activated receptor-1
Chronic kidney disease (CKD) involves interstitial fibrosis as an influential underlying
pathological process associated with compromised renal function regardless of etiological …
pathological process associated with compromised renal function regardless of etiological …