The blood-brain barrier (BBB) is vital for maintaining brain homeostasis by enabling an
exquisite control of exchange of compounds between the blood and the brain parenchyma …

The vascular blood–brain barrier is a highly regulated interface between the blood and
brain. Its primary function is to protect central neurons while signaling the presence of …

The human brain vasculature is of great medical importance: its dysfunction causes
disability and death, and the specialized structure it forms—the blood–brain barrier …

Although SARS-CoV-2 primarily targets the respiratory system, patients with and survivors of
COVID-19 can suffer neurological symptoms 1, 2, 3. However, an unbiased understanding …

Despite the importance of the cerebrovasculature in maintaining normal brain physiology
and in understanding neurodegeneration and drug delivery to the central nervous system …

Physical exercise is generally beneficial to all aspects of human and animal health, slowing
cognitive ageing and neurodegeneration. The cognitive benefits of physical exercise are …

Achieving sufficient delivery across the blood–brain barrier is a key challenge in the
development of drugs to treat central nervous system (CNS) disorders. This is particularly …

Delirium, a syndrome characterized by an acute change in attention, awareness and
cognition, is caused by a medical condition that cannot be better explained by a pre-existing …

The brain harbors a unique ability to, figuratively speaking, shift its gears. During
wakefulness, the brain is geared fully toward processing information and behaving, while …

Aging induces molecular, cellular and functional changes in the adult brain that drive
cognitive decline and increase vulnerability to dementia-related neurodegenerative …