Soluble epoxide hydrolase (sEH) is an α/β hydrolase fold protein and widely distributed in
numerous organs including the liver, kidney, and brain. The inhibition of sEH can effectively …

Overcoming poor solubility is a significant issue in drug discovery. The most common
solution is to replace carbon atoms with polar heteroatoms such as N and O or by attaching …

A new series of 4-chloro-N-(2-(substitutedphenyl)-4-oxothiazolidin-3-yl)-2-
phenoxybenzamide derivatives were designed, synthesized and biologically evaluated as …

Alzheimer's disease (AD) is a progressive mental disorder that brings a huge economic
burden to the healthcare systems. During this illness, acetylcholine levels in the cholinergic …

Recently, some inhibitors of soluble epoxide hydrolase (sEH) showed limited potential in
treating sepsis by increasing survival time, but they have unfortunately failed to improve …

Inhibition of soluble epoxide hydrolase (sEH) is considered as a promising target to reduce
blood pressure, improve insulin sensitivity, and decrease inflammation. In this study, a series …

Soluble epoxide hydrolase (sEH), a key enzyme belonging to cytochrome P450 pathway of
arachidonic acid cascade is a novel therapeutic drug target against atherosclerosis. The …

The elevation of epoxy-fatty acids through inhibition of soluble epoxide hydrolase (sEH) is
efficient for the treatment of inflammatory and pain-related diseases. Herein, we reported the …

Soluble epoxide hydrolase is a class of α/β-fold hydrolase enzymes that exist in numerous
organs and tissues, including the liver, kidney, brain, and vasculature. This homodimer …

The soluble epoxide hydrolase (sEH) enzyme plays an important role in the metabolism of
endogenous chemical mediators involved in the regulation of blood pressure and …