Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Type VII secretion systems (T7SSs) have a key role in the secretion of effector proteins in
non-pathogenic mycobacteria and pathogenic mycobacteria such as Mycobacterium …

Type VII secretion systems are membrane-embedded nanomachines used by Gram-positive
bacteria to export effector proteins from the cytoplasm to the extracellular environment. Many …

Tuberculosis (TB) is the leading cause of death due to an infectious agent, with more than
1.5 million deaths attributed to TB annually worldwide. The global dissemination of drug …

The type VII protein secretion system (T7SS) of Staphylococcus aureus is encoded at the
ess locus. T7 substrate recognition and protein transport are mediated by EssC, a …

The outcome of an encounter with Mycobacterium tuberculosis (Mtb) depends on the
pathogen's ability to adapt to the variable immune pressures exerted by the host …

Mycobacterium tuberculosis (M. tb) is an intracellular pathogen that exploits moonlighting
functions of its proteins to interfere with host cell functions. PE/PPE proteins utilize host …

The tuberculosis necrotizing toxin (TNT) is the major cytotoxicity factor of Mycobacterium
tuberculosis (Mtb) in macrophages. TNT is the C-terminal domain of the outer membrane …

Tuberculosis (TB) is among the most difficult infections to treat, requiring several months of
multidrug therapy to produce a durable cure. The reasons necessitating long treatment times …

The type VII protein secretion system (T7SS) is found in many Gram-positive bacteria and in
pathogenic mycobacteria. All T7SS substrate proteins described to date share a common …