Overview of immunosuppressive therapy in solid organ transplantation

CD Holt - Anesthesiology clinics, 2017 - anesthesiology.theclinics.com
Improvements in surgical techniques and availability of immunosuppressive options have
led to current successes in the arena of solid organ transplantation. Historically …

[HTML][HTML] A comprehensive overview of the clinical relevance and treatment options for antibody-mediated rejection associated with non-HLA antibodies

T Kardol-Hoefnagel, HG Otten - Transplantation, 2021 - journals.lww.com
Although solid organ transplant results have improved significantly in recent decades, a
pivotal cause of impaired long-term outcome is the development of antibody-mediated …

[HTML][HTML] Daratumumab for treatment of antibody-mediated rejection after ABO-incompatible kidney transplantation

D Spica, T Junker, M Dickenmann, S Schaub… - Case reports in …, 2020 - karger.com
We report the effectiveness of daratumumab, a human IgGκ monoclonal antibody targeting
CD38 on plasma cells, for therapy-refractory antibody-mediated rejection (AMR) due to …

Antibody‐mediated rejection in xenotransplantation: can it be prevented or reversed?

Z Habibabady, G McGrath, K Kinoshita… - …, 2023 - Wiley Online Library
Antibody‐mediated rejection (AMR) is the commonest cause of failure of a pig graft after
transplantation into an immunosuppressed nonhuman primate (NHP). The incidence of …

Salinosporamide A, a marine-derived proteasome inhibitor, inhibits T cell activation through regulating proliferation and the cell cycle

HS Lee, GS Jeong - Molecules, 2020 - mdpi.com
The appropriate regulation of T cell activity under inflammatory conditions is crucial for
maintaining immune homeostasis. Salinosporamide A discovered as a self-resistance …

Acute rejection following kidney transplantation: state-of-the-art and future perspectives

E Rodrigo, MF Chedid, DS Segundo… - Current …, 2020 - benthamdirect.com
Although acute renal graft rejection rate has declined in the last years, and because an
adequate therapy can improve graft outcome, its therapy remains as one of the most …

The role of long-lived plasma cells in antibody-mediated rejection of kidney transplantation: an update

H Su, CY Zhang, J Lin, HP Hammes, C Zhang - Kidney Diseases, 2019 - karger.com
Background: Antibody-mediated rejection (ABMR) following kidney transplant is closely
associated with poor prognosis of the recipients. Long-lived plasma cells (LLPCs) produce …

A bibliometric and knowledge-map analysis of antibody-mediated rejection in kidney transplantation

J Zhang, X Yu, Z Xie, R Wang, H Li, ZF Tang, N Na - Renal Failure, 2023 - Taylor & Francis
Objectives Antibody-mediated rejection (AMR) is a large obstacle to the long-term survival of
allograft kidneys. It is urgent to find novel strategies for its prevention and treatment …

The impact of induction regimes on immune responses in patients with multiple myeloma

MA Firer, MY Shapira, G Luboshits - Cancers, 2021 - mdpi.com
Simple Summary Multiple myeloma remains an essentially incurable blood cancer. New
patients with multiple myeloma are often treated with induction chemotherapy, stem cell …

Bortezomib in kidney transplant: Current use and perspectives

LR Requiao-Moura… - Current drug …, 2017 - ingentaconnect.com
Background: Despite major advances in transplant medicine, antibody-mediated rejection
(AMR) continues to have severe clinical implications and adversely affect graft survival …