Phylogenetic comparative methods comprise the general endeavor of using an estimated
phylogenetic tree (or set of trees) to make secondary inferences: about trait evolution …

Immune checkpoint inhibitors (ICI) have been revolutionary in the field of cancer therapy.
However, their success is limited to specific indications and cancer types. Recently, the …

Cells in obligately multicellular organisms by definition have aligned fitness interests,
minimum conflict, and cannot reproduce independently. However, some cells eat other cells …

Elephants have emerged as a model system to study the evolution of body size and cancer
resistance because, despite their immense size, they have a very low prevalence of cancer …

Background and objectives Cancer is a disease that affects nearly all multicellular life,
including the broad and diverse taxa of Aves. While little is known about the factors that …

Gene loss can promote phenotypic differences between species, for example, if a gene
constrains phenotypic variation in a trait, its loss allows for the evolution of a greater range of …

The explanation for why some species are more susceptible to cancer than others remains
an area of intense investigation. Cancer evolves in part through the accumulation of …

Comparative oncology—the extension of traditional oncology to study cancer across the tree
of life—provides a compelling, comprehensive framework through which to understand and …

Could diet and mean plasma glucose concentration (MPGluC) explain the variation in
cancer prevalence across species? We collected diet, MPGluC, and neoplasia data for 160 …

Life history theory offers a powerful framework to understand evolutionary selection
pressures and explain how adaptive strategies use the life history trade-off and differences …