The plasma membrane serves as the primary barrier between the cell's interior and its
external surroundings, which places it at the forefront of intercellular communication …

Ferroptosis holds great potential in cancer treatment, but its efficacy is severely limited by a
low Fenton reaction efficacy. Meanwhile, the interactive relationship between Ferroptosis …

Interorganelle membrane contact sites (MCS) are areas of close vicinity between the
membranes of two organelles that are maintained by protein tethers. Recently, a significant …

The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent
insulinotropic polypeptide receptor (GIPR), are prime therapeutic targets for the treatment of …

Lipid changes in the brain have been implicated in many neurodegenerative diseases
including Alzheimer's Disease (AD), Parkinson's disease and Amyotrophic Lateral Sclerosis …

Background Numerous studies have demonstrated that Absent in Melanoma 2 (AIM2) is
upregulated in aortic plaques, especially in Vascular Smooth Muscle Cells in Coronary …

We previously found that uptake of cellular debris prompts conventional dendritic cells
(cDCs) to undergo maturation. This transformation results in DCs entering the molecular …

The gut microbiome derived short chain fatty acids perform multitude of functions to maintain
gut homeostasis. Here we studied how butyrate stymie enteric bacterial invasion in cell …

The incretin receptors, glucagon-like peptide-1 receptor (GLP-1R) and glucose-dependent
insulinotropic polypeptide receptor (GIPR), are class B GPCRs and prime therapeutic targets …

Activation of JAK/STAT signaling by IFN-g requires partitioning of IFN-gR into specific lipid
nanodomains at the plasma membrane. Using IFN-gR as a proxy, we investigated the role of …